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The intensity of Galactic cosmic rays is nearly isotropic because of the influence of magnetic fields in the Milky Way. Here, we present two-dimensional high-precision anisotropy measurement for energies from a few to several hundred teraelectronvolts (TeV), using the large data sample of the Tibet Air Shower Arrays. Besides revealing finer details of the known anisotropies, a new component of Galactic cosmic ray anisotropy in sidereal time is uncovered around the Cygnus region direction. For cosmic-ray energies up to a few hundred TeV, all components of anisotropies fade away, showing a corotation of Galactic cosmic rays with the local Galactic magnetic environment. These results have broad implications for a comprehensive understanding of cosmic rays, supernovae, magnetic fields, and heliospheric and Galactic dynamic environments.

In the present study, DNA typing for HLA-DPB1 was performed using polymerase chain reaction (PCR)-sequence-based typing method in two isolated Chinese populations: the Blangs (n = 94) in Shuangjiang County and the Puyis (n = 76) in Luoping County from Yunnan province of Southwest China. These two populations exhibited certain similarity in their allelic distributions of the HLA-DPB1 gene. A total of 11 and 12 alleles at the DPB1 locus were found in the Blang and Puyi groups, respectively. In the Blang group, the most frequent alleles were DPB1*0501 (51.0%) and DPB1*1301 (17.0%). DPB1*030101 was also common with a frequency of 6.4%. In the Puyi group, the most frequent allele was also DPB1*0501 with a frequency of 47.5%, followed by DPB1*1301 (21.1%). Two alleles DPB1*2101 and DPB1*0202 followed, with frequencies ranging between 5% and 8%. The alleles DPB1*4101, DPB1*3301, DPB1*6801 and DPB1*8401 were found for the first time in Chinese populations. A dendrogram constructed by neighbor-joining method showed that the Blang and Puyi ethnic minorities, which had the closest relationship belonged to the southern Chinese.

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We propose to build a large water-Cherenkovtype muon-detector array (Tibet MD array) around the 37 000 m 2 Tibet air shower array (Tibet AS array) already constructed at 4300 m above sea level in Tibet, China. Each muon detector is a waterproof concrete pool, 6 m wide × 6 m long × 1.5 m deep in size, equipped with a 20 inch-indiameter PMT. The Tibet MD array consists of 240 muon detectors set up 2.5 m underground. Its total effective area will be 8640 m 2 for muon detection. The Tibet MD array will significantly improve gamma-ray sensitivity of the Tibet AS array in the 100 TeV region (10-1000 TeV) by means of gamma/hadron separation based on counting the number of muons accompanying an air shower. The Tibet AS+MD array will have the sensitivity to gamma rays in the 100 TeV region by an order of magnitude better than any other previous existing detectors in the world.Keywords Gamma ray · Cosmic ray · Muon · SNR PACS 95.55.Ka · 98.70.Sa · 95.85.Ry

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The amplitude of the Compton-Getting (CG) anisotropy contains the power-law index of the cosmic-ray energy spectrum. Based on this relation and using the Tibet air shower array data, we measure the cosmic-ray spectral index to be Ϫ3.03 ‫ע‬ 0.55 stat ‫ע‬ !0.62 syst between 6 and 40 TeV, consistent with Ϫ2.7 from direct energy spectrum measurements. Potentially, this CG anisotropy analysis can be utilized to confirm the astrophysical origin of the "knee" against models for nonstandard hadronic interactions in the atmosphere.

In this work, polymorphism of human leukocyte antigen (HLA)-DRB1, -DQB1 and -DPB1 genes was detected using polymerase chain reaction-sequence-based typing method in 128 healthy unrelated volunteers from the Bai ethnic group of Yunnan province of southwest China. Among all the 28 alleles detected for the DRB1 gene, the most common allele was DRB1*120201 with a frequency of 16.41%, followed by DRB1*090102, DRB1*080302, DRB1*1404, DRB1*150101, DRB1*140101 and DRB1*160201, with frequencies of 10.16%, 9.77%, 9.38%, 8.98%, 8.59% and 8.21%, respectively. Among 19 DQB1 alleles detected, the most frequent allele was DQB1*030101/0309 (35.94%), followed by DQB1*050201 (11.33%), DQB1*060101/060103 (10.54%) and DQB1*0401 (10.16%). For the DPB1 locus, the most common alleles were DPB1*0501 (42.19%), DPB1*1301 (13.28%), DPB1*020102 (10.93%) and DPB1*040101 (9.77%). The comparison of HLA class II allele frequencies of Bais with those of other Chinese populations suggested that the Bai ethnic group belonged to the southern group of Chinese.