A virtual database system is software that provides unified access to multiple information sources. If the sources are overlapping in their contents and independently maintained, then the likelihood of inconsistent answers is high. Solutions are often based on ranking (which sorts the different answers according to recurrence) and on fusion (which synthesizes a new value from the different alternatives according to a specific formula). In this paper we argue that both methods are flawed, and we offer alternative solutions that are based on knowledge about the performance of the source data; including features such as recentness, availability, accuracy and cost. These features are combined in a flexible utility function that expresses the overall value of a data item to the user. Utility allows us to (1) define meaningful ranking on the inconsistent set of answers, and offer the topranked answer as a preferred answer; (2) determine whether a fusion value is indeed better than the initial values, by calculating its utility and comparing it to the utilities of the initial values; and (3) discover the best fusion: the fusion formula that optimizes the utility. The advantages of such performance-based and utility-driven ranking and fusion are considerable.
microRNA expression and sequence analysis database (http://konulab.fen.bilkent.edu.tr/mirna/) (mESAdb) is a regularly updated database for the multivariate analysis of sequences and expression of microRNAs from multiple taxa. mESAdb is modular and has a user interface implemented in PHP and JavaScript and coupled with statistical analysis and visualization packages written for the R language. The database primarily comprises mature microRNA sequences and their target data, along with selected human, mouse and zebrafish expression data sets. mESAdb analysis modules allow (i) mining of microRNA expression data sets for subsets of microRNAs selected manually or by motif; (ii) pair-wise multivariate analysis of expression data sets within and between taxa; and (iii) association of microRNA subsets with annotation databases, HUGE Navigator, KEGG and GO. The use of existing and customized R packages facilitates future addition of data sets and analysis tools. Furthermore, the ability to upload and analyze user-specified data sets makes mESAdb an interactive and expandable analysis tool for microRNA sequence and expression data.
Objective: For small abdominal aortic aneurysms (AAAs), a regular follow-up examination is recommended every 12 months for AAAs of 30-39 mm and every six months for AAAs of 40-55 mm. Follow-up diameters can determine if a patient follows the common growth model of the population. However, the rapid expansion of an AAA, often associated with higher rupture risk, may be overlooked even though it requires surgical intervention. Therefore, the prognosis of abdominal aortic aneurysm growth is clinically important for planning treatment. This study aims to build enhanced Bayesian inference methods to predict maximum aneurysm diameter.Methods: 106 CT scans from 25 Korean AAA patients were retrospectively obtained. A two-step approach based on Bayesian calibration was used, and an exponential abdominal aortic aneurysm growth model (population-based) was specified according to each individual patient's growth (patient-specific) and morphologic characteristics of the aneurysm sac (enhanced). The distribution estimates were obtained using a Markov Chain Monte Carlo (MCMC) sampler.
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