In recent years, transition metal-catalyzed strong C–C
bond
activation has significantly attracted the attention of synthetic
chemists. This protocol enables simultaneous and direct functionalization
of two different M–C bonds. Among different types of C–C
bond activation strategies, strain-driven C–C bond activation
has resulted in various otherwise difficult transformations. In this
context, palladium catalyst has been extensively used and studied
due to its robust reactivity and selectivity. Herein we have briefly
discussed palladium-catalyzed C–C bond activation of three-
and four-membered cycloalkane derivatives.
A catalytic
system is discovered for the intramolecular
C–H
amidation of N-phenoxy acetamide derivatives. Herein,
a cobalt catalyst has been employed for the olefin-mediated ortho C–H functionalization. Moreover, a monocyclic
olefin, maleimide, has been used as a transient mediator instead of
well-established bicyclic norbornenes. Maleimide promotes a Co(III)
intermediate to undergo oxidative addition into the O–N bond
to form a Co(V) nitrene species and subsequently directs nitrene addition
to the ortho position. Mechanistic study and density
functional theory (DFT) study support the proposed mechanism. The
products derived from this methodology have been demonstrated as a
ligand in the C–H olefination reaction. Furthermore, the synthetic
utility of this methodology was demonstrated via the ortho-amidation of estrone.
In recent years, transition metal catalysed strong C-C bond activation has significantly attracted the attention of synthetic chemists. This enables simultaneous and direct functionalization of two different M-C bonds. Among different types of C-C bond activation strategies, strain-driven C-C bond activation has resulted in a variety of transformations, which is otherwise impossible. In this context, palladium catalyst has been extensively used and studied due to its robust nature in terms of its reactivity and selectivity. Herein, we have provided a brief discussion about palladium catalysed C-C bond activation of three and four-membered cycloalkane derivatives.
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