Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J mice. Delivered MENCs were uniformly distributed inside the brain, and were non-toxic to brain and other major organs, such as kidney, lung, liver, and spleen, and did not affect hepatic, kidney and neurobehavioral functioning.
An approach to fabrication of a patterned magnetic recording
medium for next generation data storage systems is presented.
(Co/Pd)n
magnetic multilayers are evaluated as candidates for patterned medium materials
for their high and easily controllable magnetic anisotropy. The multilayer films
deposited on a Ta seed layer enable high intergranular exchange coupling—an
essential feature of a patterned magnetic recording medium. The quality of
(Co/Pd)n
superlattices was optimized via deposition conditions and monitored using low-angle x-ray
diffraction. An estimated in-plane (hard-axis) magnetization saturation field in excess of
40 000 Oe was observed. Vertical (easy-axis) hysteresis loops for as-deposited continuous
magnetic multilayers exhibited a low coercivity of 930 Oe, indicating highly uniform
(magnetically) films with weak domain wall pinning. Ion-beam proximity lithography
was used to pattern magnetic multilayers into 43 nm islands on a 135 nm pitch.
Following patterning, easy-axis coercivity increased nearly 15-fold to 12.7 kOe.
A 16.5 mm long, heavily doped erbium-ytterbium phosphate glass-waveguide amplifier was fabricated by the femtosecond laser (fs-laser) inscription technique. The femtosecond laser inscription of waveguides was carried out at 500 kHz repetition rate using a 0.68 NA aspheric lens. The energy deposition profile in the dielectric material was initially simulated using a generalized adaptive fast-Fourier evolver (GAFFE) algorithm. The size and shape of the guiding structures were carefully controlled by the slit shaping technique to reduce the coupling losses, with achievable values down to less than 0.1 dB. Rigorous simulations of the response of the active waveguides were carried out to optimize their performance as optical amplifiers. A maximum of 8.6 dB internal gain at 1534 nm was obtained upon bidirectional laser pumping at 976 nm, leading to a gain per unit length of 5.2 dB cm −1 . Laser action was also achieved for both ring and linear cavity configurations.
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