SummaryWe identified two patients with a t(2;4)(p24;q12) and a t(4;12)(q2?3;p1?2), respectively, in association with BCR-ABL and FIP1L1-PDGFRA negative chronic eosinophilic leukaemia. Molecular analysis revealed a novel STRN-PDGFRA fusion for the t(2;4) and ETV6-PDGFRA for the t(4;12). The fusions were confirmed by specific amplification of the genomic breakpoints, reverse transcription polymerase chain reaction and fluorescence in situ hybridisation. Both patients were treated with imatinib and, following a rapid haematological response, achieved cytogenetic remission and a major molecular response. In conclusion, PDGFRA fuses to diverse partner genes in myeloid disorders. Identification of these fusions is important as they are particularly sensitive to imatinib.

Anderson previously received 13.2% share of the royalties received by the Sydney Local Health District (the owner of the intellectual property) for the use of mannitol to promote mucociliary clearance, and she is the inventor on the patent. She also owns shares of Pharmaxis Ltd worth less than US $5,000 that she purchased herself. Cipolla is a paid employee of Insmed Inc. Two of Insmed's products were discussed in these sections, including amikacin liposome inhalation suspension (ALIS, ARIKAYCE) and inhaled treprostinil palmitil. Daviskas received 16% share of the royalties received by the Sydney Local Health District (about US $10,000 per annum). She also owns shares of Pharmaxis worth less than US $3,000 that she purchased herself. Disse received compensation for consultant services from Boehringer Ingelheim, Actelion and Sanofi-Aventis in recent years. Olsson is owner of Mimetikos AB mentioned in the text.dx.