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BackgroundSalivary gland adenoid cystic carcinoma (ACC) is a rare cancer, accounting for only 1% of all head and neck malignancies. ACC is well known for perineural invasion and distant metastasis, but its underlying molecular mechanisms of carcinogenesis are still unclear.Principal FindingsHere, we show that a novel oncogenic candidate, suprabasin (SBSN), plays important roles in maintaining the anchorage-independent and anchorage-dependent cell proliferation in ACC by using SBSN shRNA stably transfected ACC cell line clones. SBSN is also important in maintaining the invasive/metastatic capability in ACC by Matrigel invasion assay. More interestingly, SBSN transcription is significantly upregulated by DNA demethylation induced by 5-aza-2′-deoxycytidine plus trichostatin A treatment and the DNA methylation levels of the SBSN CpG island located in the second intron were validated to be significantly hypomethylated in primary ACC samples versus normal salivary gland tissues.Conclusions/SignificanceTaken together, these results support SBSN as novel oncogene candidate in ACC, and the methylation changes could be a promising biomarker for ACC.

Similar to previous studies, children had weight gain after TA. In this analysis, younger age (≤ 6 years) was a significant predictor of postoperative weight gain. Future research should prospectively evaluate the association between weight gain and demographic factors in children undergoing TA, with special attention to the relationship with age.

Background The impact of delirium on survival of elderly patients remains undetermined with conflicting results from clinical studies and meta-analysis. In this study we assessed the relationship between long-term mortality and incident postoperative delirium in elderly patients undergoing hip fracture repair. Methods Patients ≥ 65 years old who were not delirious before undergoing hip fracture repair were included in a database maintained prospectively from March 1999 until July 2009. All participating patients underwent delirium assessment on the 2nd postoperative day using the confusion assessment method. Survival of the participants was determined as of October 2012. Results In 459 patients the mean (SD) period of evaluation from surgery until death or study closure was 4.1 (3.5) years with patients followed for as long as 13.6 years. Preoperative cognitive impairment was present in 120 patients (26.1%) and delirium on the 2nd postoperative day was observed in 151 (32.9%) of these. Although univariate analysis demonstrated a strong association between incident postoperative delirium and survival, this relationship did not persist in a multivariate model. Survival was a function of age at the time of surgery (p < 0.001), illness severity as determined by the ASA physical status score (p < 0.001), and duration of admission to the intensive care unit after surgery (p < 0.001). Incorporation of incident postoperative delirium did not meaningfully (p = 0.22) enhance the final survival model. In such a model, the hazard ratio [CI95] for incident postoperative delirium was 1.25 [0.92, 1.48]. Conclusions Incident postoperative delirium was not significantly associated with decreased survival in elderly patients undergoing hip fracture repair.