OK lenses for myopia induce significant structural and optical changes particularly in the central epithelium after 15 days or 1 month of wear. The central corneal epithelium responds to OK wear by undergoing significant epithelial cell shape and size alterations with no effects, however, on the cells of the corneal endothelium or the corneal stroma. Peripheral corneal thickness increased with respect to baseline values. These findings suggest that the corneal epithelium is the principal structure affected by the mechanical forces exerted by the OK lenses.
Q-values varied according to the refractive properties examined. However, the relationship between refractive state and corneal asphericity was found to be determined more by the geometric properties of the eye (corneal power and axial length) than by manifest refraction.
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