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We study 4-dimensional homology cobordisms without 3-handles via Heegaard and instanton Floer homologies, character varieties, and Thurston geometries. We provide obstructions to such cobordisms arising from each of these theories, and illustrate some topological applications.

In this paper, we discuss Floer homology of Lagrangian submanifolds in an open symplectic manifold given as the complement of a smooth divisor. Firstly, a compactification of moduli spaces of holomorphic strips in a smooth divisor complement is introduced. Next, this compactification is used to define Lagrangian Floer homology of two Lagrangians in the divisor complement. The main new feature of this paper is that we do not make any assumption on positivity or negativity of the divisor.

Kronheimer and Mrowka asked whether the difference between the four-dimensional clasp number and the slice genus can be arbitrarily large. This question is answered affirmatively by studying a knot invariant derived from equivariant singular instanton theory, and which is closely related to the Chern-Simons functional. This also answers a conjecture of Livingston about slicing numbers. Also studied is the singular instanton Frøyshov invariant of a knot. If defined with integer coefficients, this gives a lower bound for the unoriented slice genus, and is computed for quasi-alternating and torus knots. In contrast, for certain other coefficient rings, the invariant is identified with a multiple of the knot signature. This result is used to address a conjecture by Poudel and Saveliev about traceless SU p2q representations of torus knots. Further, for a concordance between knots with non-zero signature, it is shown that there is a traceless representation of the concordance complement which restricts to non-trivial representations of the knot groups. Finally, some evidence towards an extension of the slice-ribbon conjecture to torus knots is provided.

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