ObjectivesThe purpose of the present study was to evaluate the association between the red blood cell distribution width (RDW) and the Glasgow Coma Scale (GCS), Canadian Neurological Scale (CNS), and National Institutes of Health Stroke Scale (NIHSS) scores in patients who had acute ischemic stroke.MethodsThis prospective observational cohort study included 88 patients who have had acute ischemic stroke and a control group of 40 patients who were evaluated in the Emergency Department for disorders other than acute ischemic stroke. All subjects had RDW determined, and stroke patients had scoring with the GCS, CNS, and NIHSS scores. The GCS, CNS, and NIHSS scores of the patients were rated as mild, moderate, or severe and compared with RDW.ResultsStroke patients had significantly higher median RDW than control subjects. The median RDW values were significantly elevated in patients who had more severe rather than milder strokes rated with all three scoring systems (GCS, CNS, and NIHSS). The median RDW values were significantly elevated for patients who had moderate rather than mild strokes rated by GCS and CNS and for patients who had severe rather than mild strokes rated by NIHSS. The area under the receiver operating characteristic curve was 0.760 (95% confidence interval, 0.676–0.844). Separation of stroke patients and control groups was optimal with RDW 14% (sensitivity, 71.6%; specificity, 67.5%; accuracy, 70.3%).ConclusionIn stroke patients who have symptoms <24 hours, the RDW may be useful in predicting the severity and functional outcomes of the stroke.
A D-dimer level <0·35 μg/ml may exclude the diagnosis of pulmonary embolism. At a D-dimer cutoff 0·5 μg/ml and D-dimer/fibrinogen ratio cutoff 1·0, the D-dimer/fibrinogen ratio may have better specificity than D-dimer level in the diagnosis of pulmonary embolism, but the D-dimer/fibrinogen ratio may lack sufficient specificity in screening.
In the present study, low temperature-dependent physiological changes were investigated through photosynthetic activity and some endogenous mechanisms in two winter oilseed rape cultivars (Brassica napus L. ssp. oleifera cvv. Eurol and Hansen) on the basis of leaf age. Chlorophyll fluorescence measurements demonstrated that low temperature caused decreased photosynthetic activity in both cultivars. However, photosynthetic apparatus in the young leaves of Hansen is more tolerant to low temperature as demonstrated by lower F0 (minimum fluorescence yield) and 1–qp (excitation pressure of photosystem II), higher Fm (maximum fluorescence yield), Fv/Fm and non-photochemical quenching (NPQ) compared with Eurol. In addition, young leaves of Hansen represented marked increase in some antioxidant enzyme activities (superoxide dismutase (SOD), ascorbate peroxidase (APX) and glutathione reductase (GR)) during cold exposure. In the young leaves of Eurol, however, APX and GR activity was decreased by low temperature, indicating lower efficiency of ascorbate-glutathione cycle. Lower antioxidant activity in the young leaves of Eurol may be responsible for increased malondialdehyde (MDA), H2O2 and membrane damage and decreased chlorophyll content as a result of oxidative damage during cold exposure. In the cold-stressed mature leaves, both cultivars represented similar antioxidant capacities and photosynthetic efficiency. As a consequence, coordinated increase in SOD, APX and GR activities, increased capacity to keep quinone A (QA) in an oxidised state (as indicated by lower 1–qp) and accumulation of soluble sugar and proline could be mainly attributed to higher level of tolerance of the young leaves of Hansen to low temperature when compared with Eurol.
The effect of pre-treatment with 200 mM NaCl on the response of four barley cultivars (Hordeum vulgare L. cv. to UV-B radiation was investigated. Salt stress as well as UV-B irradiation led to a decrease of the total chlorophyll (chl) content in all cultivars, except in Kalaycı-97. While carotenoids are almost not affected by NaCl treatment, UV-B irradiation caused an increase by 5-20% of carotenoid content of all cultivars. UV-B induced damages of photosynthetic apparatus were estimated by the rate of photosynthetic electron transport measured by chl fluorescence and the rate of oxygen evolution, the latter being more affected. Pre-treatment with NaCl alleviated harmful effect of UV-B irradiation on F v /F m and ETR, but not on oxygen evolution. UV-B-induced and UV-B-absorbing compounds with absorption at 300 and 438 nm increased as a result of UV-B treatment. The level of stress marker proline increased considerably as a result of NaCl treatment, while UV-B irradiation resulted in a pronounced increase of the level of H 2 O 2 . MDA enhanced in the seedlings subjected to salt and UV-B stress. Established cross-acclimation to UV-B as a result of salt treatment could be due to the increased free proline and the level of UV-B absorbing compounds in barley seedlings subjected to NaCl.
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