NiO-based films and nanostructured materials have received an increasing attention for a variety of technological applications. Among the possible strategies for their fabrication, atomic layer deposition (ALD) and chemical vapor...
Two new ‘hybrid’ metallodrugs of Au(III)
(AuTAML)
and Cu(II) (CuTAML) were designed featuring a tamoxifen-derived pharmacophore
to ideally synergize the anticancer activity of both the metal center
and the organic ligand. The compounds have antiproliferative effects
against human MCF-7 and MDA-MB 231 breast cancer cells. Molecular
dynamics studies suggest that the compounds retain the binding activity
to estrogen receptor (ERα). In vitro and in silico studies showed that the Au(III) derivative is
an inhibitor of the seleno-enzyme thioredoxin reductase, while the
Cu(II) complex may act as an oxidant of different intracellular thiols.
In breast cancer cells treated with the compounds, a redox imbalance
characterized by a decrease in total thiols and increased reactive
oxygen species production was detected. Despite their different reactivities
and cytotoxic potencies, a great capacity of the metal complexes to
induce mitochondrial damage was observed as shown by their effects
on mitochondrial respiration, membrane potential, and morphology.
Racemic 3-substituted oxindoles were successfully converted into enantiomerically pure or enriched material (up to 99 % ee) upon irradiation at λ = 366 nm in the presence of a chiral benzophenone catalyst (10 mol %). The photochemical deracemization process allows predictable editing of the stereogenic center at carbon atom C3. Light energy compensates for the associated loss of entropy and enables the decoupling of potentially reversible reactions, i.e. a hydrogen atom transfer to (photochemical) and from (thermal) the carbonyl group of the catalyst. The major enantiomer is continuously enriched in several catalytic cycles. The obtained oxindoles were shown to be valuable intermediates for further transformations, which proceeded with complete retention at the stereogenic center.
With the aim of designing new metallosupramolecular architectures for drug delivery, research has focused on porous 3-dimentional (3D)-metallacages able to encapsulate cytotoxic agents protecting them from metabolism while targeting them...
A new pseudo-rotaxane, consisting of a tubular, organometallic Ag-pillarplex ring and dodecyldiammonium axle component, is introduced and investigated towards potential non-covalent interactions by Full Interaction Maps (FIMs). FIMs predict regions of probable supramolecular interactions solely at the organic ligands, namely the rim and the aromatic rings of the pillarplex. The results were compared to structural parameters experimentally obtained by single-crystal X-ray diffraction. The pseudo-rotaxane was crystallized as a hydrated terephthalate salt, and the molecular and the crystal structure are discussed. The experimentally observed interactions are quantified using Hirshfeld surface analysis. In contrast to the FIMs prediction, four different interaction modes can be experimentally observed in the solid-state: encapsulation of a guest molecule, hydrogen bonding, π- and metal interactions.
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