Highlights d Anti-PD-1 efficacy depends on intratumoral activity of the CXCR3 chemokine system d CD103 + dendritic-cell-derived CXCL9 and CXCR3 on CD8 + T cells are required d CXCR3 ligands are positive indicators of responsiveness to anti-PD-1 therapy d Inducing CXCR3 ligands in non-responsive tumors restores sensitivity to anti-PD-1
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