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Heroin dependence is associated with increased insulin resistance in hepatitis C virus seronegative heroin dependents. Prolonged heroin use is associated with reduction of basal β-cell pancreatic function with decreased insulin resistance controlled for waist circumference, but still inducing significantly decreased basal insulin sensitivity.

Highlights Acute OP poisoning complicated with pulmonary thrombosis during the first week of poisoning. Antidote treatment included atropine, whereas diazepam was administered in the first 48 h. There was no administration of oximes due to unavailability. Prolonged hypoxemia in acute OP intoxication indicates exclusion of thrombotic pulmonary event.