Primary squamous cell carcinoma of the liver is exceedingly rare and has previously been reported in association with hepatic teratoma, hepatic cyst or hepatolithiasis. This paper describes an autopsy case of squamous cell carcinoma which developed with hypercalcemia in a cirrhotic liver. This cancer was characterized histologically, immunohistologically and ultrastructurally, and was found to exhibit immunofluorescence positivity for anti-epidermal keratin monoclonal antibody, together with the presence of tonofflaments scattered sparsely in the cytoplasm of the cancer cells. ACTA PATHOL JPN 38: 643-6!50,1988.
In a double-blind clinical trial, 24 patients with advanced chronic liver disease received 1.2 g of nicotinohydroxamic acid daily and 23 patients received 1.5 g of neomycin. Patients receiving nicotinohydroxamic acid showed significant improvement in blood ammonia levels as compared to patients receiving neomycin. Nicotinohydroxamic acid induced some side effects, such as mild diarrhea, constipation and anorexia, but less than in cases of neomycin.
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