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We propose the simple pulse source, in which the pulses generated by large-signal directly modulated laser diode are phase-modulated, and then compressed into short pulses by an optimized length of DCF. On the one hand, phase modulator is used to enhance the negative chirp of large-signal directly modulated pulses. On the other hand, the largesignal directly modulated pulses are used to suppress the pedestal produced by the phase modulator. Using this technique, highly stable 10-GHz 5.5-ps optical pulses are obtained, which suppress pedestal up to 20dB and have a low timing jitter of 184fs.

Polyamidoamine (PAMAM)-entrapped Au nanoparticles were synthesized with distinct sizes to figure out the size effect of Au-based contrast agent on CT imaging of passively targeted tissues. Au/PAMAM nanoparticles were first synthesized with narrow distribution of particles size of 22.2 ± 3.1, 54.2 ± 3.7, and 104.9 ± 4.7 nm in diameters. Size effect leads no significant difference on X-ray attenuation when Au/PAMAM was ≤0.05 mol/L. For CT imaging of a tumor model, small Au/PAMAM were more easily internalized via endocytosis in the liver, leading to more obviously enhanced contrast. Similarly, contrast agents with small sizes were more effective in tumor imaging because of the enhanced permeability and retention effect. Overall, the particle size of Au/PAMAM heavily affected the efficiency of CT enhancement in imaging RES and tumors.

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