These studies clearly demonstrate the existence of an avian reservoir of remarkably diverse bornaviruses and provide a compelling candidate in the search for an etiologic agent of PDD.

Background: Proventricular dilatation disease (PDD) is a fatal disorder of psittacine birds worldwide. The disease is characterized by lymphoplasmacytic infiltration of the central and peripheral nervous systems, leading to gastrointestinal motility and/or central nervous system dysfunction. Recently, we detected a significant association between avian bornavirus (ABV) infection and clinical signs of PDD in psittacines. However, it remains unclear whether ABV infection actually causes PDD. To address this question, we examined the impact of ABV inoculation on the cockatiel (Nymphicus hollandicus).

Proventricular dilatation disease (PDD) is a fatal inflammatory disease that affects mainly, but not exclusively, psittacine birds (Order: Psittaciformes). PDD has long been suspected to be a viral disease, but its causative agent, a novel Bornavirus, was only identified in 2008.

Susceptibility of North American owls to WNV is associated with native breeding range.

This study describes the macroscopic and microscopic lesions and the viral antigen distribution in 82 owls (Family: Strigidae) of 11 North American and one Eurasian species that died following natural West Nile virus infection. The range of lesions seen was greater than that previously reported for owls, and involved more organs. Two patterns of antigen distribution were identified: one that involved the blood and all major organs; and a second where antigen was sparse, localized, and absent from the blood. The first pattern was associated with species of northern natural breeding range, while the second was seen in owls of a more southern distribution and appeared to be associated with a more prolonged course of illness. Further differences in lesion and antigen distribution appeared to be either species related or individual. The findings underline the complexity and variability of West Nile virus pathology within birds of a relatively narrow taxonomic group.