Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and control subjects and hierarchical data analysis revealed that transcripts encoding proteins involved in the regulation of presynaptic function (PSYN) were decreased in all subjects with schizophrenia. Genes of the PSYN group showed a different combination of decreased expression across subjects. Over 250 other gene groups did not show altered expression. Selected PSYN microarray observations were verified by in situ hybridization. Two of the most consistently changed transcripts in the PSYN functional gene group, N-ethylmaleimide sensitive factor and synapsin II, were decreased in ten of ten and nine of ten subjects with schizophrenia, respectively. The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model.

In this study, the development of models for the design of an anaerobic upflow filters separated into two and three phases are presented, DI-FAFS and TRI-FAFS. Both reactors have been evaluated in the COD removal performance on a total of 54 tests. The experimentalfactors are the volumetric organic load, the temperature and the depth relationship between two consective phases. The conceptual modelis based on equations derived from a mass balance under stationary conditions dS/dt = 0 and advectives dS/dZ ≠ 0; eight equationsapplicable to the DI-FAFS and TRI-FAFS reactors; four equations for each reactor.The equations to obtain the parameters of degradationof organic matter were compared with bibliographic references. Two models were selected and proposed, after adjusted to observationswith R2 adjusted greater than 0.7 and with standard errors of estimation and the absolute average error in the minimum values.

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This paper constitutes a novel proposal for predicting the accumulation–utilization rate for transport of the organochlorine pesticides (OCPs) as well as the kinetic coefficients of biodegradation of OCPs dissolved in water and sorbed on sediments in tropical rivers. Eight OCPs were determined in waters and sediments in the dry and rainy seasons from 2013 to 2016. The biochemical transport and transformation model was proposed in two directions, along the river false(∂COCP/∂xfalse)$({\partial {C_{{\rm{OCP}}}}/\partial x} )$, and across the river (direction z$z$), false(∂COCP/∂zfalse)$({\partial {C_{{\rm{OCP}}}}/\partial z} )$, providing kinetic parameters linked to Monod's equation under a steady‐state condition for particulate and soluble OCPs, being useful for designing bioremediation techniques to restore water bodies.