Preliminary findings suggest non-acute ischaemic stroke patients can improve their cardiovascular fitness and reduce their CRS with a cardiac rehabilitation programme. The intervention was associated with improvement in self-reported depression.
Equilibrium constants for keto-enol tautomerisation and migration of hydrogen from carbon to nitrogen to form enamine or zwitterion tautomers have been measured for COPh) in aqueous solution at 25 "C. Relative tautomeric stabilities fall in the order ketoimine > enamine > enol and (for the 3-isomer) enol > zwitterion. Values of pKT, (-log KT) where KT = [enamine (or zwitterion)]/[imine] or [enol]/[ketone], are 1.05, 5.87 and 2.42 for the enamine or zwitterion tautomerism and 2.0, 4.86 and 4.4 for keto-enol tautomerism of the 2-, 3-and 4-isomers respectively. For the enamines KT was determined kinetically by quenching the enolate anion at a pH below its pKa and monitoring its relaxation to the ketoimine spectrophotometrically: combining rate constants for this process and the reverse reaction measured by halogen trapping of the enol or enamine gave KT. Values are compared with results * This pK, was earlier estimated4 as 8.4 instead of 8.1 and the derived pK, for the keto-enol tautomerisation as 4.2 instead of 4.4. The present values are preferred.
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