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Abstract:The coherent elastic scattering of neutrinos off nuclei has eluded detection for four decades, even though its predicted cross-section is the largest by far of all low-energy neutrino couplings. This mode of interaction provides new opportunities to study neutrino properties, and leads to a miniaturization of detector size, with potential technological applications. We observe this process at a 6.7-sigma confidence level, using a low-background, 14.6-kg CsI [Na] scintillator exposed to the neutrino emissions from the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory. Characteristic signatures in energy and time, predicted by the Standard Model for this process, are observed in high signal-to-background conditions. Improved constraints on non-standard neutrino interactions with quarks are derived from this initial dataset.The characteristic most often associated with neutrinos is a very small probability of interaction with other forms of matter, allowing them to traverse astronomical objects while undergoing no energy loss. As a result, large targets (tons to tens of kilotons) are used for their detection. The discovery of a weak neutral current in neutrino interactions (1) implied that neutrinos were capable of coupling to quarks through the exchange of neutral Z bosons. Soon thereafter it was suggested that this mechanism should also lead to coherent interactions between neutrinos and all nucleons present in an atomic nucleus (2). This possibility would exist only as long as the momentum exchanged remained significantly smaller than the inverse of the nuclear size ( Fig. 1A), effectively restricting the process to neutrino energies below a few tens of MeV.The enhancement to the probability of interaction (scattering cross-section) would however be very large when compared to interactions with isolated nucleons, approximately scaling with the square of the number of neutrons in the nucleus (2, 3). For heavy nuclei and sufficiently intense neutrino sources, this can lead to a dramatic reduction in detector mass, down to a few kilograms.Coherent elastic neutrino-nucleus scattering (CEnNS) has evaded experimental demonstration for forty-three years following its first theoretical description. This is somewhat surprising, in view of the magnitude of its expected cross-section relative to other tried-andtested neutrino couplings (Fig. 1B), and of the availability of suitable neutrino sources: solar, atmospheric and terrestrial, supernova bursts, nuclear reactors, spallation facilities, and certain radioisotopes (3). This delay stems from the difficulty in detecting the low-energy (few keV) nuclear recoil produced as the single outcome of the interaction. Compared to a minimum ionizing particle of the same energy, a recoiling nucleus has a diminished ability to generate measurable scintillation or ionization in common radiation detector materials. This is exacerbated by a trade-off between the enhancement to the CEnNS cross-section brought about by a large nuclear mass, and the smaller maxi...