Sildenafil (Viagra) prolongs repolarisation in cardiac muscle, an effect that could lead to ventricular fibrillation (VF). Sildenafil (2 mg kg À1) was given by mouth to 12 mongrel dogs and, 24 h later, these dogs were anaesthetised, thoracotomised and subjected to a 25 min occlusion of the anterior descending coronary artery. Haemodynamic parameters were similar in this and the control group, but there were fewer and less serious ventricular arrhythmias during occlusion in the sildenafil group (VF 17 vs 60%; ventricular premature beats 140752 vs 4377127% and episodes of ventricular tachycardia 4.073.2 vs 19.377.7%, all Po0.05). However, reperfusion VF and indices of ischaemia severity (epicardial ST-segment mapping, inhomogeneity) were not modified by the drug. Sildenafil increased the QT interval, especially during ischaemia. Our conclusion is that ischaemia-induced ventricular arrhythmias are reduced by sildenafil, but this protection is less pronounced than that following cardiac pacing or exercise.

Thymidylate synthase (TS) gene polymorphisms are important as prognostic factors in cancer chemotherapy, but recent results describe that the TS enhancer region (TSER) polymorphic genotypes may also modulate risk for malignancies. Two functionally important and ethnically diverse polymorphisms are present on the TS transcript, TSER, a repeat polymorphism (2 or 3 repeats; 2R, 3R) affecting TS expression, and a 6 bp ins/del polymorphism on the 3 UTR (position TS1494, del6 or ins6), which may influence mRNA stability. Hungarian population has one of the highest colorectal cancer (CRC) mortality rates in Europe, and several elevated dietary risk factors affect a large part of the population. In our study (99 primary CRC cases), population analysis of the patient group genotype frequencies revealed a departure from the Hardy-Weinberg equilibrium and significant heterozygote deficiency (p < 0.05) at the TSER locus. Despite the strong linkage between the 2 polymorphic loci, case TS1494del genotype frequencies were normally distributed, as well as the genotype frequencies of the healthy control population (n ‫؍‬ 102), at both loci. Case-control comparison demonstrated a lower relative risk of TSER heterozygotes (OR ‫؍‬ 0.47; CI ‫؍‬ 0.27-0.83; p ‫؍‬ 0.008) and a possible higher prevalence of the 3R3R&ins6/del6 in the CRC group. The observation that heterozygotes are those less susceptible for CRC in the Hungarian population may support the possibility of 2 different pathways in which TS may play a role in colorectal carcinogenesis, probably nutrient (or folate)-dependently. The lack of similar genotype effect seen with TS1494del polymorphism and the increased presence of one genotype combination (3R3R&ins6/del6) in the patient group suggest a possible TS haplotype effect influencing CRC risk.

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The aim of this study is to analyse data concerning 15-24-year-old Hungarian women to estimate the prevalence of anorexia nervosa, bulimia nervosa and subclinical eating disorders. A cross-sectional representative survey was conducted among 3615 young women using a self-report questionnaire. The point prevalence of anorexia nervosa was 0.03%, of bulimia nervosa 0.41%, of subclinical anorexia nervosa 1.09% and of subclinical bulimia nervosa 1.48%. Our results show that 6.3% of the sample were 'dieting' daily, 7% exercised daily, 2.7% reported binge eating, and use of laxatives, diet pills and self-induced vomiting at least twice a week was reported by 0.7%, 0.9% and 0.2%, respectively. This study was the first to be conducted on a nationally representative sample of young women in Hungary.

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