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Sci Rep 2018 DOI: 10.1038/s41598-018-28371-4 View Full Text
Eun-Hui Lee, Michal Itan, Jinsun Jang, Hyeon-Jung Gu, Perri Rozenberg, Melissa K. Mingler, Ting Wen, Jiyoung Yoon, Shi-Young Park, Joo Young Roh, Cheol Soo Choi, Woo-Jae Park, Ariel Munitz, YunJae Jung et al.

Abstract: Accumulating data have indicated a fundamental role of eosinophils in regulating adipose tissue homeostasis. Here, we performed whole-genome RNA sequencing of the small intestinal tract, which suggested the presence of impaired lipid metabolism in eosinophil-deficient ΔdblGATA mice. ΔdblGATA mice fed a high-fat diet (HFD) showed reduced body fat mass, impaired enlargement of adipocytes, decreased expression of adipogenic genes, and developed glucose intolerance. HFD induced accumulation of eosinophils in the p…

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