Biochemical Medicine and Metabolic Biology volume 50, issue 2, P176-185 1993 DOI: 10.1006/bmmb.1993.1059
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D.E. Comings, S.D. Flanagan, G. Dietz, D. Muhleman, E. Knell, R. Gysin
Abstract:

Dopamine plays a major role in the regulation of appetite and growth hormone. Dopaminergic agonists suppress appetite and dopamine D2 receptor antagonists enhance it. We examined the hypothesis that allelic variants of the DRD2 locus may be associated with weight and height. Sarkar and Sommer described two DRD2 polymorphisms that could be haplotyped by PCR. For weight, the mean Z score (National Center for Health Statistics) for 208 subjects without haplotype 4 was 0.086 versus 0.557 for 280 subjects with …

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