Obesity volume 17, issue 9, P1657-1663 2009 DOI: 10.1038/oby.2009.192
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Swarup K. Chakrabarti, Banumathi K. Cole, Yeshao Wen, Susanna R. Keller, Jerry L. Nadler
Abstract:

Inflammation and insulin resistance associated with visceral obesity are important risk factors for the development of type 2 diabetes, atherosclerosis, and the metabolic syndrome. The 12/15‐lipoxygenase (12/15‐LO) enzyme has been linked to inflammatory changes in blood vessels that precede the development of atherosclerosis. The expression and role of 12/15‐LO in adipocytes have not been evaluated. We found that 12/15‐LO mRNA was dramatically upregulated in white epididymal adipocytes of high‐fat fed mice…

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