2006
DOI: 10.1038/nature05483
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Abstract: Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways. In particular, their role in calorie storage makes adipocytes well suited to the regulation of energy balance. Adipose tissue also serves as a crucial integrator of glucose homeostasis. Knowledge of adipocyte biology is therefore crucial for understanding the pathophysiological basis o… Show more

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Cited by 1,827 publications
(1,543 citation statements)
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References 121 publications
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“…Leptin was reduced with increasing levels of restriction and was strongly positively correlated with adiposity (Mitchell et al ., 2015b). As leptin is a key regulator of long‐term energy balance, its reduction during CR may be antagonistically regulating S1P and ceramide (Rosen & Spiegelman, 2006). Although no direct relationship between leptin signalling and S1P or ceramide has yet been discovered, and we found the relationship between these metabolites and leptin may be completely explained by adiposity, low levels of ceramide have been associated previously with reduced mass and improved insulin signalling in the liver and muscle tissue in ob/ob and obese mice (Yang et al ., 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Leptin was reduced with increasing levels of restriction and was strongly positively correlated with adiposity (Mitchell et al ., 2015b). As leptin is a key regulator of long‐term energy balance, its reduction during CR may be antagonistically regulating S1P and ceramide (Rosen & Spiegelman, 2006). Although no direct relationship between leptin signalling and S1P or ceramide has yet been discovered, and we found the relationship between these metabolites and leptin may be completely explained by adiposity, low levels of ceramide have been associated previously with reduced mass and improved insulin signalling in the liver and muscle tissue in ob/ob and obese mice (Yang et al ., 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Adipose tissue is the largest energy storage reservoir and has critical role in controlling the whole-body energy balance. 4,[36][37] Adipose tissue also functions as important endocrine organ and secretes numerous cytokines and hormones that regulate global energy homeostasis. 38 In human, adipogenesis is mainly occurred during the process of embryo development and the turnover of adipocytes in adult adipose tissues.…”
Section: Discussionmentioning
confidence: 99%
“…The differentiation programme is triggered when this receptor is activated, with another two members of the CCAAT/enhancer-binding family (CEBPB and CEBPD) driving PPARG expression in the early stages of differentiation and CEBPA being responsible for maintaining PPARG expression later in the process. These two factors reciprocally regulate each other and activate terminal differentiation genes, and CEBPA plays an additional supporting role in maintaining specific aspects of the adipocyte phenotype, including insulin sensitivity (Rosen and Spiegelman, 2006). According to this paradigmatic model, a positive relationship between PPARG and CEBPA expression is thus to be expected.…”
Section: Marbling and Adipositymentioning
confidence: 99%