Vitex Agnus-Castus extract (Ze 440) improves symptoms in women with menstrual cycle irregularities

Eltbogen, Roger; Litschgi, M; Gasser, Urs; Nebel, S; Zahner, Catherine

doi:10.1055/s-0034-1394507

Cited by 5 publications

(4 citation statements)

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“…In an observational study conducted on 211 females with complain of Polymenorrhea, Oligomenorrhoea, Amenorrhea, Dysmenorrhea, Menometrorrhagia; the use of 20mg VAC for 3 menstrual cycles has shown improvement in menstrual cycle irregularities among 79-85% also 60-88% females showed improvement in menstrual bleeding disorders [13].…”

Section: Clinical Evidences Of Use Of Vac In Various Gynecological Conditionsmentioning

confidence: 99%

Non Hormonal Management of Menstrual Cylce Irregularities

Faruqui¹

2018

JGWH

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Each month the endometrium becomes inflamed, and the luminal portion is shed during menstruation. Aberrations in menstrual physiology can lead to common gynecological conditions, such as heavy or prolonged bleeding. Menstrual dysfunction is defined in terms of bleeding patterns, for example, amenorrhea, menorrhagia or polymenorrhea; ovarian dysfunction for example, anovulation and luteal deficiency; painful menstruation and premenstrual syndrome. Certain characteristics of menstruation can be a reflection of an underlying pathologic process or may predispose a woman to the development of chronic disease. For example, metrorrhagia predisposes to anemia, and the irregular menstrual cycles associated with PCOS (see PCOS) can predispose a woman to infertility, diabetes and consequently, heart disease.What is it, in this age of life-saving antibiotics, hormonal therapy, surgeries and other seemingly miraculous medical therapies that causes so many individuals to seek therapies outside of conventional medicine? Conventional medicine may be at its best when treating acute crises, but for the treatment of chronic problems it may fall short of offering either cure or healing, leading patients to seek out systems of treatment that they perceive as addressing the causes of their problem, not just the symptoms. According to WHO, experience has shown that there are real benefits in the long term use of whole medicinal plants and their extracts, since the constituents in them work in conjunction with each other. Globally, it is estimated that 70% of all health care is provided by traditional, nonconventional medicine. Vitex agnus castus or chaste tree is one such herb which has a long history of use for common gynecological complaints.

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Section: Clinical Evidences Of Use Of Vac In Various Gynecological Conditionsmentioning

confidence: 99%

Non Hormonal Management of Menstrual Cylce Irregularities

Faruqui¹

2018

JGWH

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“…Циклічна масталгія різної інтенсивності виникає щомісяця не менш ніж у 70% жінок, а постійний біль в області молочних залоз (МЗ) середнього та важкого ступеня тяжкості наявний приблизно у 50% пацієнток із доброякісними «мастопатіями» [2,6,9]. Мастодинія призводить до фізичного, емоційного і функціонального дискомфорту, заважає виконувати щоденні дії, погіршує сон, харчування та нерідко супроводжується порушенням когнітивних функцій [1,2,4,10].…”

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Vitex agnus-castus Ze 440 extract in the therapy of cyclic mastodynia in women with non-tumor breast damage

Kovaliov

Alivapova²

2021

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Cyclic mastalgia of varying intensity occurs every month in at least 70% of women, persistent pain in the mammary glands of moderate and severe degree is occur in about 50% of patients with benign mastopathy. The cause of mastodynia is the morphofunctional rearrangement of the glandular and stromal components of tissues with the expansion of ducts and proliferation of epithelial structures due to a lack of progesterone and an increase in prolactin levels. Therapy for cyclical and chronic mastalgia is empirical and not always effective. Herbal medicine with Vitex agnus-castus is a reasonable alternative to hormonal treatment for women suffering from cyclic mastalgia in combination with other manifestations of premenstrual syndrome. The main effect of such drugs is an increase of luteinizing hormone and progesterone synthesis, effect on the hypothalamic-pituitary system, prolactin and endorphins release, which can increase the level of endogenous opioids.Purpose of the study: to study the effect of the phytopreparation Prefemin (Vitex agnus-castus extract Ze 440) on the intensity of chronic pain syndrome in women with diffuse non-tumor breast lesion. Materials and methods. The study involved 30 women aged 22 to 43 years with various types of benign breast diseases and chest pain lasting at least 3 months. In 12 patients there was diffuse fibroadenoma, in 18 – diffuse cystofibroadenoma (small cystic variant) and duct ectasia.Results. Therapy with Prefemin (Ze 440) allowed to completely eliminate pain syndrome in 93.3% of women and to reduce the frequency of mastodynia in the group with moderate severity in 90.0% of patients with diffuse fibroadenoma and cystofibroadenoma.Conclusions. Phytopreparation Prefemin, which is obtained from the medicinal plant Vitex agnus-castus, has demonstrated high efficacy in the mastalgia treatment in women with diffuse fibrocystic breast disease. This drug was well tolerated and there were no side effects.

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“…Many clinical trials confirm the health-promoting effects of V. agnus-castus L. [101][102][103][104][105][106][107][108]. Table 3 reports the results of the main clinical trial studies.…”

Section: Health-promoting Activities Of Vitex Agnus-castus L In Humamentioning

confidence: 99%

Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives

Souto

Durazzo²,

Nazhand

et al. 2020

Forests

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Medicinal plants are used worldwide due to their lower risk of side effects and eco-friendly, cost-effective production when compared to chemical drugs, encouraging researchers to further exploit the therapeutic potential of the former. One of the most popular medicinal plants is Vitex agnus-castus L., grown in tropical and sub-tropical regions, to which different health benefits have already been attributed. In this perspective article, the in vitro and in vivo therapeutic properties of V. agnus-castus L. have been analyzed and reviewed with a special focus on its health-promoting effects and potential nutraceutical applications.

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Vitex Agnus-Castus extract (Ze 440) improves symptoms in women with menstrual cycle irregularities

Cited by 5 publications

References 0 publications

Non Hormonal Management of Menstrual Cylce Irregularities

Non Hormonal Management of Menstrual Cylce Irregularities

Vitex agnus-castus Ze 440 extract in the therapy of cyclic mastodynia in women with non-tumor breast damage

Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives

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