Effects of multiple pulmonary aspirations of enteral solutions on lung tissue damage

Ameliorative effect of Leflunomide on lung injury following an aspiration

“…In our study, we observed a signifi cant increase in PICI, ASI, AED, AEX, and AHI in lung tissue in the histopathological examination after FOR and HCl aspiration. This fi nding is similar to that reported in other working models, which demonstrated a comparable damage after gastric content aspiration (20,24,25).…”

Ameliorative effect of Leflunomide on lung injury following an aspiration

“…In our study, we observed a signifi cant increase in PICI, ASI, AED, AEX, and AHI in lung tissue in the histopathological examination after FOR and HCl aspiration. This fi nding is similar to that reported in other working models, which demonstrated a comparable damage after gastric content aspiration (20,24,25).…”

The effect of hyperbaric oxygen treatment on aspiration pneumonia

“…A standard diagnostic finding in lipoid pneumonia is the observation of macrophages (Ahrens et al 1999), which help in the diagnosis of chronic pulmonary aspiration (Bauer and Lyrene 1999;Umuroglu et al 2006). These findings suggested that multiple pulmonary aspirations of the enteral solutions studied resulted in chronic, rather than acute or subacute, histopathological changes.…”

Exogenous lipoid pneumonia. Clinical and radiological manifestations

“…3,6e8,27,30 Critically ill patients receiving nasoenteric feeding may easily develop aspiration pneumonia, as a result of a retrograde regurgitation of feeding solutions. 31 In some countries the digestive form of Chagas disease, where patients with megacolon have severe and prolonged periods of constipation (over 60 days), should also be remembered. 32,33 The combination of two factors (constipation caused by functional disorder of colon, and tendency to aspiration due to megaesophagus) enhances the risk of lipoid pneumonia in patients with Chagas disease.…”

Ameliorative effect of Leflunomide on lung injury following an aspiration

“…In our study, we observed a signifi cant increase in PICI, ASI, AED, AEX, and AHI in lung tissue in the histopathological examination after FOR and HCl aspiration. This fi nding is similar to that reported in other working models, which demonstrated a comparable damage after gastric content aspiration (20,24,25).…”

The effect of hyperbaric oxygen treatment on aspiration pneumonia

“…A standard diagnostic finding in lipoid pneumonia is the observation of macrophages (Ahrens et al 1999), which help in the diagnosis of chronic pulmonary aspiration (Bauer and Lyrene 1999;Umuroglu et al 2006). These findings suggested that multiple pulmonary aspirations of the enteral solutions studied resulted in chronic, rather than acute or subacute, histopathological changes.…”

Exogenous lipoid pneumonia. Clinical and radiological manifestations

“…3,6e8,27,30 Critically ill patients receiving nasoenteric feeding may easily develop aspiration pneumonia, as a result of a retrograde regurgitation of feeding solutions. 31 In some countries the digestive form of Chagas disease, where patients with megacolon have severe and prolonged periods of constipation (over 60 days), should also be remembered. 32,33 The combination of two factors (constipation caused by functional disorder of colon, and tendency to aspiration due to megaesophagus) enhances the risk of lipoid pneumonia in patients with Chagas disease.…”

Ameliorative effect of Leflunomide on lung injury following an aspiration

“…In our study, we observed a signifi cant increase in PICI, ASI, AED, AEX, and AHI in lung tissue in the histopathological examination after FOR and HCl aspiration. This fi nding is similar to that reported in other working models, which demonstrated a comparable damage after gastric content aspiration (20,24,25).…”

The effect of hyperbaric oxygen treatment on aspiration pneumonia

“…A standard diagnostic finding in lipoid pneumonia is the observation of macrophages (Ahrens et al 1999), which help in the diagnosis of chronic pulmonary aspiration (Bauer and Lyrene 1999;Umuroglu et al 2006). These findings suggested that multiple pulmonary aspirations of the enteral solutions studied resulted in chronic, rather than acute or subacute, histopathological changes.…”

Exogenous lipoid pneumonia. Clinical and radiological manifestations

“…3,6e8,27,30 Critically ill patients receiving nasoenteric feeding may easily develop aspiration pneumonia, as a result of a retrograde regurgitation of feeding solutions. 31 In some countries the digestive form of Chagas disease, where patients with megacolon have severe and prolonged periods of constipation (over 60 days), should also be remembered. 32,33 The combination of two factors (constipation caused by functional disorder of colon, and tendency to aspiration due to megaesophagus) enhances the risk of lipoid pneumonia in patients with Chagas disease.…”