Antimicrobial Peptides: Delivery by Dendritic Mesoporous Silica Nanoparticles Enhances the Antimicrobial Activity of a Napsin‐Derived Peptide Against Intracellular Mycobacterium tuberculosis (Adv. Healthcare Mater. 14/2021)

Abstract

In article number 2100453 by Steffen Stenger, Mika Lindén, and co‐workers, the activity of the antimicrobial peptide NapFab against intracellular Mycobacterium tuberculosis (Mtb) is significantly increased by loading onto dendritic mesoporous silica nanoparticles (DMSN). This enhanced activity is based on a 30‐fold increased, DMSN‐mediated peptide uptake. Livecell fluorescence microscopy and electron microscopy reveal fast DMSN uptake in endosomal vesicles, intracellular degradation of the carrier, and a continuous peptide release.

Metal-coordination-driven self-assembly of DNA nanohybrids for robust intracellular anti-tuberculosis therapy

“…Advancements in nanotechnology have enabled the development of anti-TB nanotherapeutics that offer improved effectiveness. [5][6][7][8][9][10][11][12][13][14] Liao and collaborators have demonstrated that macrophage membrane-coated photothermal agents can selectively accumulate in TB granulomas, enabling effective internalization and elimination of Mtb through photothermal effects. 5 Photothermal and photodynamic effects produced by nanoparticles coated with biomimetic erythrocyte membrane to target TB granuloma have also been proved to kill Mtb effectively, decreasing pathological damage simultaneously.…”

Metal-coordination-driven self-assembly of DNA nanohybrids for robust intracellular anti-tuberculosis therapy

“…Advancements in nanotechnology have enabled the development of anti-TB nanotherapeutics that offer improved effectiveness. [5][6][7][8][9][10][11][12][13][14] Liao and collaborators have demonstrated that macrophage membrane-coated photothermal agents can selectively accumulate in TB granulomas, enabling effective internalization and elimination of Mtb through photothermal effects. 5 Photothermal and photodynamic effects produced by nanoparticles coated with biomimetic erythrocyte membrane to target TB granuloma have also been proved to kill Mtb effectively, decreasing pathological damage simultaneously.…”

Advanced drug delivery and therapeutic strategies for tuberculosis treatment

“…MSNs can be used as carriers for the delivery of silver nanoparticles to target sites because they have very high bactericidal potency. A 2D hexagonal MSN containing silver bromide also showed good antimycobacterial activity [228].…”

Metal-coordination-driven self-assembly of DNA nanohybrids for robust intracellular anti-tuberculosis therapy

“…Advancements in nanotechnology have enabled the development of anti-TB nanotherapeutics that offer improved effectiveness. [5][6][7][8][9][10][11][12][13][14] Liao and collaborators have demonstrated that macrophage membrane-coated photothermal agents can selectively accumulate in TB granulomas, enabling effective internalization and elimination of Mtb through photothermal effects. 5 Photothermal and photodynamic effects produced by nanoparticles coated with biomimetic erythrocyte membrane to target TB granuloma have also been proved to kill Mtb effectively, decreasing pathological damage simultaneously.…”

Advanced drug delivery and therapeutic strategies for tuberculosis treatment

“…MSNs can be used as carriers for the delivery of silver nanoparticles to target sites because they have very high bactericidal potency. A 2D hexagonal MSN containing silver bromide also showed good antimycobacterial activity [228].…”

Metal-coordination-driven self-assembly of DNA nanohybrids for robust intracellular anti-tuberculosis therapy

“…Advancements in nanotechnology have enabled the development of anti-TB nanotherapeutics that offer improved effectiveness. [5][6][7][8][9][10][11][12][13][14] Liao and collaborators have demonstrated that macrophage membrane-coated photothermal agents can selectively accumulate in TB granulomas, enabling effective internalization and elimination of Mtb through photothermal effects. 5 Photothermal and photodynamic effects produced by nanoparticles coated with biomimetic erythrocyte membrane to target TB granuloma have also been proved to kill Mtb effectively, decreasing pathological damage simultaneously.…”

Advanced drug delivery and therapeutic strategies for tuberculosis treatment

“…MSNs can be used as carriers for the delivery of silver nanoparticles to target sites because they have very high bactericidal potency. A 2D hexagonal MSN containing silver bromide also showed good antimycobacterial activity [228].…”