Memory self‐appraisal and depressive symptoms in people at genetic risk for Alzheimer's disease

Small, Gary W.; Chen, Stephen T.; Komo, Scott; Ercoli, Linda M.; Miller, Karen J.; Siddarth, Prabha; Kaplan, Andrea; Dorsey, Deborah; Lavretsky, Helen; Saxena, Sanjaya; Bookheimer, Susan Y.

doi:10.1002/gps.481

Cited by 33 publications

(28 citation statements)

References 35 publications

(29 reference statements)

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“…On the other hand, in a sample of people at familial risk for Alzheimer's disease, depression and memory complaints were more strongly associated in the absence of e4 [19]. In this sample we found no evidence for associations between SMI and e4 in participants either with or without depression.…”

Section: Discussioncontrasting

confidence: 44%

See 1 more Smart Citation

Subjective Memory Impairment, Cognitive Function and Depression – A Community Study in Older Koreans

Kim

Stewart²,

Shin

et al. 2003

Dement Geriatr Cogn Disord

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Correlates of subjective memory impairment (SMI) were investigated using data from a community study of 1,204 individuals aged 65 or over in an urban and rural area of South Korea. SMI and depression were ascertained from the Geriatric Mental State Schedule and cognitive function from the Korean version of the Mini-Mental State Examination (MMSE-K). 686 participants had also completed the MMSE-K two years earlier. SMI was present in 22% of the sample and was associated with depression and lower MMSE-K scores. Depression and SMI were most strongly associated in the presence of cognitive impairment. SMI was weakly associated with previous cognitive decline and was not associated with APOE e4. SMI and cognitive impairment were most strongly associated in urban residents, particularly rural-to-urban migrants.

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Section: Discussioncontrasting

confidence: 44%

“…In one study, depression was found to be more strongly associated with SMI in the presence of e4 [2], but in another study the association was strongest in its absence [19].…”

Section: Introductionmentioning

confidence: 99%

Subjective Memory Impairment, Cognitive Function and Depression – A Community Study in Older Koreans

Kim

Stewart²,

Shin

et al. 2003

Dement Geriatr Cogn Disord

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“…The association between depressive symptoms and subjective memory complaints has been widely reported (Beck et al, 1974;Blackburn & Eunson, 1989;Derouesne et al, 1999;Small et al, 2001;Turvey et al, 2000). A number of components influence subjective memory complaints.…”

Section: Associations With Subjective Memorymentioning

confidence: 99%

“…Older adults with intact memory who self-report memory problems often have higher rates of depression (Turvey, Schultz, Arndt, Wallace, & Herzog, 2000). Subjective memory complaints may be the presentation of depression or may co-exist with depressive symptoms (Small et al, 2001) more often than with true cognitive decline (Derouesne et al, 1999;Jungwirth et al, 2004;Pearman & Storandt, 2004). However, the processes underlying the relationship between reports of memory loss and depressive symptoms are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

The link between depressive symptoms, negative cognitive bias and memory complaints in older adults

Crane

Bogner

Brown

et al. 2007

Aging & Mental Health

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Objectives-We sought to examine the relationship between depressive symptoms and subjective memory problems. We hypothesized that the relationship between depressive symptoms and poor subjective memory functioning is mediated by negative cognitive bias that is associated with hopelessness, a wish to die and low self-esteem.Methods-Complete data were available for 299 older adults with and without significant depressive symptoms who were screened in primary care offices and invited to participate, completed a baseline in-home assessment. Subjective memory functioning and psychological status was assessed with commonly used, validated standard questionnaires.Results-In regression models that included terms for age, gender and cognitive measures, depressive symptoms were significantly inversely associated with the global self-assessment of memory (β = −0.019; p = 0.006). When components of negative cognitive bias were included in the model (hopelessness, low self-esteem, a wish to die), the relationship of depressive symptoms with subjective memory problems was attenuated, consistent with mediation.Conclusions-Our results suggest that assessment and successful interventions for memory complaints in non-demented older adults need to account for negative cognitive bias as well as depressive symptoms. Longitudinal research is needed to confirm our findings before a mediator relationship can be presumed.

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“…Mutation of apoE has been linked to Alzheimer's disease (47); age-related memory disorders are also associated with apoE signaling (48). ApoE receptor signaling is directly involved in the dephosphorylation of tau protein and may have neuroprotective activity (49).…”

Section: Late Gene Expression Changes Of Mice In Enriched Environmentmentioning

confidence: 99%

Effects of environmental enrichment on gene expression in the brain

Rampon

Jiang

Dong

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

555

359

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Memory self‐appraisal and depressive symptoms in people at genetic risk for Alzheimer's disease

Abstract: These results confirm that mild depressive symptoms are related to subjective memory loss, but for some forms of memory complaint, the relationship holds true only for people without the major known genetic risk for Alzheimer's disease.

Cited by 33 publications

References 35 publications

Subjective Memory Impairment, Cognitive Function and Depression – A Community Study in Older Koreans

Subjective Memory Impairment, Cognitive Function and Depression – A Community Study in Older Koreans

The link between depressive symptoms, negative cognitive bias and memory complaints in older adults

Effects of environmental enrichment on gene expression in the brain

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