Memory self‐appraisal and depressive symptoms in people at genetic risk for Alzheimer's disease

Abstract

These results confirm that mild depressive symptoms are related to subjective memory loss, but for some forms of memory complaint, the relationship holds true only for people without the major known genetic risk for Alzheimer's disease.

Risk factors of major depression in the elderly

“…Subjective memory impairment is a risk factor of depression in the elderly. This finding is in accordance with several previous studies reporting an association of subjective memory impairment [62] or cognitive impairment [25,65] with depression. On the other hand some authors favour the hypothesis, that depression causes subjective memory impairment or cognitive impairment [19,45,57] or the hypothesis of a comorbidity of cognitive impairment and depression [21].…”

Risk factors of major depression in the elderly

“…Subjective memory impairment is a risk factor of depression in the elderly. This finding is in accordance with several previous studies reporting an association of subjective memory impairment [62] or cognitive impairment [25,65] with depression. On the other hand some authors favour the hypothesis, that depression causes subjective memory impairment or cognitive impairment [19,45,57] or the hypothesis of a comorbidity of cognitive impairment and depression [21].…”

Memory complaints in a community sample aged 60–64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities

“…The present study showed no association between APOE genotype and memory complaints, in contrast to clinical studies by Small et al (1999) and Laws et al (2002), but in agreement with larger community studies by Dik et al (2001) and Kim et al (2003). We also failed to find any interaction between APOE and depression in determining subjective memory complaints, contrary to Small et al (2001) and Stewart et al (2001). Statistical power is always an issue when reporting negative results.…”

Subjective Memory Impairment, Cognitive Function and Depression – A Community Study in Older Koreans

“…On the other hand, in a sample of people at familial risk for Alzheimer's disease, depression and memory complaints were more strongly associated in the absence of e4 [19]. In this sample we found no evidence for associations between SMI and e4 in participants either with or without depression.…”

Risk factors of major depression in the elderly

“…Subjective memory impairment is a risk factor of depression in the elderly. This finding is in accordance with several previous studies reporting an association of subjective memory impairment [62] or cognitive impairment [25,65] with depression. On the other hand some authors favour the hypothesis, that depression causes subjective memory impairment or cognitive impairment [19,45,57] or the hypothesis of a comorbidity of cognitive impairment and depression [21].…”

Memory complaints in a community sample aged 60–64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities

“…The present study showed no association between APOE genotype and memory complaints, in contrast to clinical studies by Small et al (1999) and Laws et al (2002), but in agreement with larger community studies by Dik et al (2001) and Kim et al (2003). We also failed to find any interaction between APOE and depression in determining subjective memory complaints, contrary to Small et al (2001) and Stewart et al (2001). Statistical power is always an issue when reporting negative results.…”

Subjective Memory Impairment, Cognitive Function and Depression – A Community Study in Older Koreans

“…On the other hand, in a sample of people at familial risk for Alzheimer's disease, depression and memory complaints were more strongly associated in the absence of e4 [19]. In this sample we found no evidence for associations between SMI and e4 in participants either with or without depression.…”

Risk factors of major depression in the elderly

“…Subjective memory impairment is a risk factor of depression in the elderly. This finding is in accordance with several previous studies reporting an association of subjective memory impairment [62] or cognitive impairment [25,65] with depression. On the other hand some authors favour the hypothesis, that depression causes subjective memory impairment or cognitive impairment [19,45,57] or the hypothesis of a comorbidity of cognitive impairment and depression [21].…”

Memory complaints in a community sample aged 60–64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities

“…The present study showed no association between APOE genotype and memory complaints, in contrast to clinical studies by Small et al (1999) and Laws et al (2002), but in agreement with larger community studies by Dik et al (2001) and Kim et al (2003). We also failed to find any interaction between APOE and depression in determining subjective memory complaints, contrary to Small et al (2001) and Stewart et al (2001). Statistical power is always an issue when reporting negative results.…”

Subjective Memory Impairment, Cognitive Function and Depression – A Community Study in Older Koreans

“…On the other hand, in a sample of people at familial risk for Alzheimer's disease, depression and memory complaints were more strongly associated in the absence of e4 [19]. In this sample we found no evidence for associations between SMI and e4 in participants either with or without depression.…”