Intraperitoneal recombinant interleukin-2 activates leukocytes in rat endometriosis

Lymphocytes in Endometriosis

“…Indeed, the defect of T‐lymphocyte cytotoxicity was corrected by stimulating peripheral blood lymphocytes with recombinant interleukin (IL)‐2, 10 implying therapeutic potential of IL‐2 for endometriosis. Consistently, IL‐2 treatment decreased the size of endometriosis‐like lesion with greater number of lymphocytes recruited to the lesion in the rat model of endometriosis 11 …”

Lymphocytes in Endometriosis

“…Indeed, the defect of T‐lymphocyte cytotoxicity was corrected by stimulating peripheral blood lymphocytes with recombinant interleukin (IL)‐2, 10 implying therapeutic potential of IL‐2 for endometriosis. Consistently, IL‐2 treatment decreased the size of endometriosis‐like lesion with greater number of lymphocytes recruited to the lesion in the rat model of endometriosis 11 …”

The Promises of Natural Killer Cell Therapy in Endometriosis

“…At the last measurement, the size was also significantly different from the placebo group. Furthermore, peritoneal NK cells and DCs were enhanced in rats with endometriosis treated with IL-2, and a greater number of activated lymphocytes, macrophages, NK cells, and DCs was observed in the implants [ 41 ].…”

Evaluation of estrogen in endometriosis patients: Regulation of GATA‐3 in endometrial cells and effects on Th2 cytokines

“…Previous studies have shown that IFN‐γ suppressed the proliferation of endometrial interstitial cells and induced their apoptosis. In contrast, IL‐2 increased the cytotoxicity of natural killer cells and induced the production of cytokines, such as IFN‐γ and TNF‐α . Levels of IL‐2 reflect changes in cellular immunity; such detection can accurately reveal the activation state of the immunity of an organism.…”

“…In contrast, IL-2 increased the cytotoxicity of natural killer cells and induced the production of cytokines, such as IFN-γ and TNF-α. 17,[34][35][36][37] Levels of IL-2 reflect changes in cellular immunity; such detection can accurately reveal the activation state of the immunity of an organism. Abnormal expression of IL-2 may free EM from the effects of immunity and leads to the expansion of the abdominal cavity.…”

Lymphocytes in Endometriosis

“…Indeed, the defect of T‐lymphocyte cytotoxicity was corrected by stimulating peripheral blood lymphocytes with recombinant interleukin (IL)‐2, 10 implying therapeutic potential of IL‐2 for endometriosis. Consistently, IL‐2 treatment decreased the size of endometriosis‐like lesion with greater number of lymphocytes recruited to the lesion in the rat model of endometriosis 11 …”

The Promises of Natural Killer Cell Therapy in Endometriosis

“…At the last measurement, the size was also significantly different from the placebo group. Furthermore, peritoneal NK cells and DCs were enhanced in rats with endometriosis treated with IL-2, and a greater number of activated lymphocytes, macrophages, NK cells, and DCs was observed in the implants [ 41 ].…”

Evaluation of estrogen in endometriosis patients: Regulation of GATA‐3 in endometrial cells and effects on Th2 cytokines

“…Previous studies have shown that IFN‐γ suppressed the proliferation of endometrial interstitial cells and induced their apoptosis. In contrast, IL‐2 increased the cytotoxicity of natural killer cells and induced the production of cytokines, such as IFN‐γ and TNF‐α . Levels of IL‐2 reflect changes in cellular immunity; such detection can accurately reveal the activation state of the immunity of an organism.…”

“…In contrast, IL-2 increased the cytotoxicity of natural killer cells and induced the production of cytokines, such as IFN-γ and TNF-α. 17,[34][35][36][37] Levels of IL-2 reflect changes in cellular immunity; such detection can accurately reveal the activation state of the immunity of an organism. Abnormal expression of IL-2 may free EM from the effects of immunity and leads to the expansion of the abdominal cavity.…”

Lymphocytes in Endometriosis

“…Indeed, the defect of T‐lymphocyte cytotoxicity was corrected by stimulating peripheral blood lymphocytes with recombinant interleukin (IL)‐2, 10 implying therapeutic potential of IL‐2 for endometriosis. Consistently, IL‐2 treatment decreased the size of endometriosis‐like lesion with greater number of lymphocytes recruited to the lesion in the rat model of endometriosis 11 …”

The Promises of Natural Killer Cell Therapy in Endometriosis

“…At the last measurement, the size was also significantly different from the placebo group. Furthermore, peritoneal NK cells and DCs were enhanced in rats with endometriosis treated with IL-2, and a greater number of activated lymphocytes, macrophages, NK cells, and DCs was observed in the implants [ 41 ].…”

Evaluation of estrogen in endometriosis patients: Regulation of GATA‐3 in endometrial cells and effects on Th2 cytokines

“…Previous studies have shown that IFN‐γ suppressed the proliferation of endometrial interstitial cells and induced their apoptosis. In contrast, IL‐2 increased the cytotoxicity of natural killer cells and induced the production of cytokines, such as IFN‐γ and TNF‐α . Levels of IL‐2 reflect changes in cellular immunity; such detection can accurately reveal the activation state of the immunity of an organism.…”

“…In contrast, IL-2 increased the cytotoxicity of natural killer cells and induced the production of cytokines, such as IFN-γ and TNF-α. 17,[34][35][36][37] Levels of IL-2 reflect changes in cellular immunity; such detection can accurately reveal the activation state of the immunity of an organism. Abnormal expression of IL-2 may free EM from the effects of immunity and leads to the expansion of the abdominal cavity.…”