Intraperitoneal recombinant interleukin-2 activates leukocytes in rat endometriosis

Velasco, Irene; Quereda, Francisco; Bermejo, Rosa Barroso; Campos, Adolfo; Acién, Pedro

doi:10.1016/j.jri.2006.12.001

Cited by 21 publications

(12 citation statements)

References 28 publications

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“…Indeed, the defect of T‐lymphocyte cytotoxicity was corrected by stimulating peripheral blood lymphocytes with recombinant interleukin (IL)‐2, 10 implying therapeutic potential of IL‐2 for endometriosis. Consistently, IL‐2 treatment decreased the size of endometriosis‐like lesion with greater number of lymphocytes recruited to the lesion in the rat model of endometriosis 11 …”

Section: T Lymphocytesmentioning

confidence: 56%

Lymphocytes in Endometriosis

Osuga

Koga

Hirota

et al. 2010

American Journal of Reproductive Immunology

147

107

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Endometriosis is a disease characterized by the presence of endometriotic tissue outside the uterine cavity. Although its pathogenesis remains to be elucidated, immune status is suggested to play an important role in the initiation and the progression of the disease. In particular, immune cells in lymphoid lineage that comprised T and B lymphocytes and natural killer cells play essential roles in determining either accept or reject survival, implantation, and proliferation of endometrial and endometriotic cells. Numerous studies have shown aberrant functions of these immune cells in women with endometriosis. The abnormalities include reduced activity of cytotoxic T cells and NK cells, cytokine secretion by helper T cells, and autoantibody production by B lymphocytes. These alterations are suggested to be induced by various manners and promote the disease. Understanding of these immune aspects in endometriosis is thus expected to benefit the treatment of the disease.

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Section: T Lymphocytesmentioning

confidence: 56%

Lymphocytes in Endometriosis

Osuga

Koga

Hirota

et al. 2010

American Journal of Reproductive Immunology

147

107

View full text Add to dashboard Cite

show abstract

“…3A). IL-2 is one of the Th1-derived cytokines that stimulates the proliferation and differentiation of B cells, T cells and NK cells (Anderson et al 1993;Zhou et al 2003) and has been shown to reduce endometriosis in rats (Velasco et al 2006;Sel'kov and Pavlov 2007;Quereda et al 2008). A significant impairment of IL-2 level of peritoneal fluid has also been demonstrated in endometriosis (Ho et al 1996).…”

Section: Gene Expression Analysis Of Peritoneal Cellsmentioning

confidence: 99%

Lactobacillus gasseri OLL2809 inhibits development of ectopic endometrial cell in peritoneal cavity via activation of NK cells in a murine endometriosis model

et al. 2011

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We have previously reported that peritoneal administration of interleukin-12 (IL-12) suppresses development of ectopic endometriotic lesions via activation of natural killer (NK) cells in a mouse endometriosis model. Lactobacillus gasseri OLL2809 is one of a probiotic lactobacillus that has been selected on an ability to stimulate production of IL-12 from murine splenocytes. In this study, we examined whether the oral administration of heatkilled L. gasseri OLL2809 suppressed development of endometriosis. Administration of L. gasseri OLL2809 for 21 consecutive days resulted in reduction of the development of ectopic endometriotic lesions in an extent similar to IL-12. Although obvious effects of L. gasseri OLL2809 on the peritoneal cytokine levels, population of peritoneal cells as well as cytotoxicity of splenic NK cells, gene expression analysis of the peritoneal cells revealed enhancement in the transcription of IL-2 and natural killer cell triggering receptor 1 genes. Therefore, it was suggested that L. gasseri OLL2809 suppressed development of endometriosis via activation of NK cells.

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“…Previous studies have shown that IFN‐γ suppressed the proliferation of endometrial interstitial cells and induced their apoptosis. In contrast, IL‐2 increased the cytotoxicity of natural killer cells and induced the production of cytokines, such as IFN‐γ and TNF‐α . Levels of IL‐2 reflect changes in cellular immunity; such detection can accurately reveal the activation state of the immunity of an organism.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, IL-2 increased the cytotoxicity of natural killer cells and induced the production of cytokines, such as IFN-γ and TNF-α. 17,[34][35][36][37] Levels of IL-2 reflect changes in cellular immunity; such detection can accurately reveal the activation state of the immunity of an organism. Abnormal expression of IL-2 may free EM from the effects of immunity and leads to the expansion of the abdominal cavity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of estrogen in endometriosis patients: Regulation of GATA‐3 in endometrial cells and effects on Th2 cytokines

Chen

Wang

Liang

2016

J of Obstet and Gynaecol

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Aims: Endometriosis (EM) is a hormone-dependent chronic inflammatory disease, usually accompanied by a high level of localized estrogen and abnormal levels of cytokines, which are regulated by GATA-3 in lymphocytes. This study aimed to investigate the role of estrogen on GATA-3 expression and the relationship between GATA-3 and cytokine response. Methods: Endometrial tissues collected from 20 patients who underwent laparoscopic or open surgery were used. Immunohistochemistry, quantitative polymerase chain reaction, Western blot analysis, cell transfection, estrogen treatments and enzyme-linked immunosorbent assays were performed to evaluate the effects of estrogen on GATA-3 expression and the relationship between estrogen-induced GATA-3 and the Th2 immune status of EM. Results: Estrogen regulated the expression of GATA-3 in a dose and time-dependent manner. GATA-3 was relocated from the cytoplasm to the nucleus. Estrogen and GATA-3 regulated Th2 cytokine expression in eutopic endometrial cells, including interleukin (IL)-6, IL-8 and IL-10. Moreover, interferon-γ and IL-2 were highly expressed in the GATA-3 knockdown groups. Conclusion: In summary, GATA-3 was induced by estrogen and may promote the occurrence and development of EM by regulating the secretion of cytokines in the eutopic endometrial cells of EM patients.

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Intraperitoneal recombinant interleukin-2 activates leukocytes in rat endometriosis

Cited by 21 publications

References 28 publications

Lymphocytes in Endometriosis

Lymphocytes in Endometriosis

Lactobacillus gasseri OLL2809 inhibits development of ectopic endometrial cell in peritoneal cavity via activation of NK cells in a murine endometriosis model

Evaluation of estrogen in endometriosis patients: Regulation of GATA‐3 in endometrial cells and effects on Th2 cytokines

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