Vascular thalamic amnesia: A reappraisal

The Role of the Anterior Thalamic Nuclei in the Genesis of Memory Disorders in Alzheimer’s Disease: An Exploratory Study

“…Finally, consistently with the demonstrated central contribution of the ATN to episodic memory functioning [9,12], we found that microstructural changes at the level of ATN, but not at the MDTN, were significantly associated with poor episodic memory in the overall aMCI and AD groups. This failure to find a direct link between MDTN damage and declarative memory impairment is consistent with previous literature [12,13,18], which overall demonstrated that episodic memory deficits are quite consistently observed following mammillo- thalamic tract/ATN damage, whereas it is not still clear if damage restricted to the MDTN is sufficient to impair declarative memory [11]. The finding that only the left ATN correlated with verbal episodic memory impairments in the patients' group supports the widely-demonstrated left hemispheric lateralization of verbal memory abilities [39] and is consistent with previous studies [40].…”

The Role of the Anterior Thalamic Nuclei in the Genesis of Memory Disorders in Alzheimer’s Disease: An Exploratory Study

“…Finally, consistently with the demonstrated central contribution of the ATN to episodic memory functioning [9,12], we found that microstructural changes at the level of ATN, but not at the MDTN, were significantly associated with poor episodic memory in the overall aMCI and AD groups. This failure to find a direct link between MDTN damage and declarative memory impairment is consistent with previous literature [12,13,18], which overall demonstrated that episodic memory deficits are quite consistently observed following mammillo- thalamic tract/ATN damage, whereas it is not still clear if damage restricted to the MDTN is sufficient to impair declarative memory [11]. The finding that only the left ATN correlated with verbal episodic memory impairments in the patients' group supports the widely-demonstrated left hemispheric lateralization of verbal memory abilities [39] and is consistent with previous studies [40].…”

Evolution of Neuropsychological Deficits in First-Ever Isolated Ischemic Thalamic Stroke and Their Association With Stroke Topography: A Case-Control Study

“…10,37,38 Previous studies in paramedian stroke patients yielded mixed results. Some studies contrary to our study specifically observed memory deficits 9,13,14,39 whereas other studies, like our study, showed a broader range of cognitive deficits. 2,4,5,19 Some studies analyzed cognitive deficits during the first days poststroke, 14 while other studies analyzed cognitive deficits in the chronic phase 1 to 5 years poststroke.…”

Multiple thalamo-cortical disconnections in anterior thalamic infarction: Implications for thalamic mechanisms of memory and language

“…These results are consistent with previous reviews of thalamic infarcts and our previous PET study, in which the functions of the frontal and temporal cortices were predominantly affected by anterior thalamic infarcts (Carlesimo et al, 2011;Nishio et al, 2011;Schmahmann, 2003;Van der Werf et al, 2000). Although the connections between the anterior portion of the thalamus, the posterior cortices, brainstem and cerebellum have not been given much attention in human studies, these fiber connections have been demonstrated in previous connectional neuroanatomical studies in animals (Jones, 2007;Schmahmann & Pandya, 2006).…”

The Role of the Anterior Thalamic Nuclei in the Genesis of Memory Disorders in Alzheimer’s Disease: An Exploratory Study

“…Finally, consistently with the demonstrated central contribution of the ATN to episodic memory functioning [9,12], we found that microstructural changes at the level of ATN, but not at the MDTN, were significantly associated with poor episodic memory in the overall aMCI and AD groups. This failure to find a direct link between MDTN damage and declarative memory impairment is consistent with previous literature [12,13,18], which overall demonstrated that episodic memory deficits are quite consistently observed following mammillo- thalamic tract/ATN damage, whereas it is not still clear if damage restricted to the MDTN is sufficient to impair declarative memory [11]. The finding that only the left ATN correlated with verbal episodic memory impairments in the patients' group supports the widely-demonstrated left hemispheric lateralization of verbal memory abilities [39] and is consistent with previous studies [40].…”

Evolution of Neuropsychological Deficits in First-Ever Isolated Ischemic Thalamic Stroke and Their Association With Stroke Topography: A Case-Control Study

“…10,37,38 Previous studies in paramedian stroke patients yielded mixed results. Some studies contrary to our study specifically observed memory deficits 9,13,14,39 whereas other studies, like our study, showed a broader range of cognitive deficits. 2,4,5,19 Some studies analyzed cognitive deficits during the first days poststroke, 14 while other studies analyzed cognitive deficits in the chronic phase 1 to 5 years poststroke.…”

Multiple thalamo-cortical disconnections in anterior thalamic infarction: Implications for thalamic mechanisms of memory and language

“…These results are consistent with previous reviews of thalamic infarcts and our previous PET study, in which the functions of the frontal and temporal cortices were predominantly affected by anterior thalamic infarcts (Carlesimo et al, 2011;Nishio et al, 2011;Schmahmann, 2003;Van der Werf et al, 2000). Although the connections between the anterior portion of the thalamus, the posterior cortices, brainstem and cerebellum have not been given much attention in human studies, these fiber connections have been demonstrated in previous connectional neuroanatomical studies in animals (Jones, 2007;Schmahmann & Pandya, 2006).…”

The Role of the Anterior Thalamic Nuclei in the Genesis of Memory Disorders in Alzheimer’s Disease: An Exploratory Study

“…Finally, consistently with the demonstrated central contribution of the ATN to episodic memory functioning [9,12], we found that microstructural changes at the level of ATN, but not at the MDTN, were significantly associated with poor episodic memory in the overall aMCI and AD groups. This failure to find a direct link between MDTN damage and declarative memory impairment is consistent with previous literature [12,13,18], which overall demonstrated that episodic memory deficits are quite consistently observed following mammillo- thalamic tract/ATN damage, whereas it is not still clear if damage restricted to the MDTN is sufficient to impair declarative memory [11]. The finding that only the left ATN correlated with verbal episodic memory impairments in the patients' group supports the widely-demonstrated left hemispheric lateralization of verbal memory abilities [39] and is consistent with previous studies [40].…”

Evolution of Neuropsychological Deficits in First-Ever Isolated Ischemic Thalamic Stroke and Their Association With Stroke Topography: A Case-Control Study

“…10,37,38 Previous studies in paramedian stroke patients yielded mixed results. Some studies contrary to our study specifically observed memory deficits 9,13,14,39 whereas other studies, like our study, showed a broader range of cognitive deficits. 2,4,5,19 Some studies analyzed cognitive deficits during the first days poststroke, 14 while other studies analyzed cognitive deficits in the chronic phase 1 to 5 years poststroke.…”

Multiple thalamo-cortical disconnections in anterior thalamic infarction: Implications for thalamic mechanisms of memory and language

“…These results are consistent with previous reviews of thalamic infarcts and our previous PET study, in which the functions of the frontal and temporal cortices were predominantly affected by anterior thalamic infarcts (Carlesimo et al, 2011;Nishio et al, 2011;Schmahmann, 2003;Van der Werf et al, 2000). Although the connections between the anterior portion of the thalamus, the posterior cortices, brainstem and cerebellum have not been given much attention in human studies, these fiber connections have been demonstrated in previous connectional neuroanatomical studies in animals (Jones, 2007;Schmahmann & Pandya, 2006).…”