Zinc in Cognitive Impairment and Aging

Abstract

Zinc, an essential micronutrient for life, was first discovered in 1869 and later found to be indispensable for the normal development of plants and for the normal growth of rats and birds. Zinc plays an important role in many physiological and pathological processes in normal mammalian brain development, especially in the development of the central nervous system. Zinc deficiency can lead to neurodegenerative diseases, mental abnormalities, sleep disorders, tumors, vascular diseases, and other pathological conditions, which can cause cognitive impairment and premature aging. This study aimed to review the important effects of zinc and zinc-associated proteins in cognitive impairment and aging, to reveal its molecular mechanism, and to highlight potential interventions for zinc-associated aging and cognitive impairments.

Association of PM2.5 Components with Acceleration of Aging: Moderating Role of Sex Hormones

“…However, current studies on K and Zn in PM 2.5 and aging are very limited. Available findings show that zinc in serum can act as an antioxidant and anti-inflammatory agent, reducing the level of oxidative stress and inflammatory factors in the body, thus having a protective effect against aging. , Zinc supplements may be used to improve aging. There is no direct evidence that K has a beneficial effect on aging.…”

Signaling pathway mechanisms of neurological diseases induced by G protein‐coupled receptor 39

“…Based on previous studies, ZnR/GPR39 activity could enhance neuronal inhibitory tone, and Zn deficiency is associated with epilepsy and seizures, indicating the important physiological role of ZnR/GPR39. 6 , 7 , 8 , 9 …”

“…In numerous experiments, Zn plays an essential physiological role in vivo. 6 As a highly specific ZnR, GPR39 is expressed in many tissues in vivo, which indicates that GPR39 may be involved in various pathophysiological roles in vivo. In the nervous system, previous results show that GPR39 has positive and beneficial neuroprotective effects on the nervous system.…”

“…Based on previous studies, ZnR/ GPR39 activity could enhance neuronal inhibitory tone, and Zn deficiency is associated with epilepsy and seizures, indicating the important physiological role of ZnR/GPR39. [6][7][8][9] Human GPR39 is a single-copy gene localized on chromosome 2 q21-q22, and it encodes the 453 amino acid GPR39 protein, 1 which is primarily expressed in the pancreas, liver, adipose tissue, and gastrointestinal tract. Recently, GPR39 was found to be expressed in mouse oviduct epithelium, with weak expression in the jugular and isthmus.…”

Zinc Acetate Dihydrate Tablet-Associated Gastritis Occurring in a Post-Hematopoietic Stem Cell Transplant Recipient

“…Low-birth-weight infants, pregnant women, and the elderly are prone to zinc defciency. Chronic liver disease, short bowel syndrome, diabetes, chronic renal disease, long-term use of chelating agents, parenteral nutrition, and tube feeding with insufcient zinc supplementation may also cause zinc defciency [1][2][3][4][5][6]. Zinc defciency leads to taste disorders, dermatitis, hair loss, anemia, stomatitis, male sexual dysfunction, increased susceptibility to infections, and osteoporosis.…”