Users' Knowledge About Adverse Effects of Non-steroidal Anti-inflammatory Drugs in Tirana, Albania

Roshi, Dajana; Toçi, Ervin; Burazeri, Genc; Schröder‐Bäck, Peter; Malaj, Ledjan; Brand, Helmut

doi:10.5455/msm.2017.29.138-142

Cited by 10 publications

(11 citation statements)

References 14 publications

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“…It should be noted that this study did not investigate paracetamol use. Roshi et al (13) reported the most commonly used painkillers to be paracetamol, ketoprofen, and ibuprofen, respectively. A similar study from Greece found that paracetamol and ibuprofen, respectively, were the most commonly used painkillers, followed by diclofenac and meloxicam (14).…”

Section: Discussionmentioning

confidence: 99%

Awareness among patients taking oral non-steroidal anti-inflammatory drugs as analgesics: a cross-sectional study

Coşkuner

Yılmaz

2021

Journal of Health Sciences and Medicine

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Aim: Non-steroidal anti-inflammatory drugs (NSAIDs), the most used drugs for pain management, are among the most commonly prescribed drugs both in the world and in Turkey. NSAIDs have a serious side effect profile, and their inappropriate use can result in adverse outcomes, including mortality. This study aimed to determine consciousness level of drug use among patients who used oral NSAIDs for pain relief. Material and Method: This was a cross-sectional and descriptive study. The universe of the study consisted of patients aged ≥18 years who presented to the Ankara City Hospital Family Medicine Outpatient Clinic at the end of 2019 for any reason who used at least one type of oral NSAID for pain relief. Data were collected using a questionnaire developed by the researchers. Awareness was measured via a survey concerning knowledge and attitude, and knowledge and attitude scores were calculated for each participant. Significance was determined at a p<0.05 level. Results: There were 210 participants. The most used NSAID was diclofenac. The most common reasons for analgesics use were headache and musculoskeletal pain. Participants had poor knowledge of the diseases associated with NSAID use, and the most well-known diseases were stomach ulcer and bleeding and kidney failure. Participants' average knowledge scores were low, and average attitude scores were relatively higher. Women had significantly higher knowledge scores than men. Knowledge and attitude scores were positively associated with education and income status. Analgesics use was positively correlated with age and negatively correlated with attitude scores. Participants with chronic diseases had lower attitude scores than those without chronic diseases. Knowledge and attitude scores were positively correlated. Conclusion:We conclude that participants lacked knowledge about the general characteristics of and risks associated with NSAIDs, widely used, over-the-counter drugs that are found in almost every home. A more cost-effective, knowledgeable, and rational approach is required for NSAID use.

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Section: Discussionmentioning

confidence: 99%

Awareness among patients taking oral non-steroidal anti-inflammatory drugs as analgesics: a cross-sectional study

Coşkuner

Yılmaz

2021

Journal of Health Sciences and Medicine

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“…The high incidence of adverse effects, lack of safety usage, and limited knowledge ofthe adverse effects of NSAIDs and their drug interactions have been reported among patients or pharmacy clients. [ 13 19 20 ] In addition, the easy access of most NSAIDs as OTC medications makes its consumers more vulnerable to the associated adverse effects. [ 19 20 ] In Saudi Arabia, both nonprescribed and prescribed NSAIDs can be bought from the pharmacy without a prescription or healthcare instructions in most cases.…”

Section: Introductionmentioning

confidence: 99%

“…[ 13 19 20 ] In addition, the easy access of most NSAIDs as OTC medications makes its consumers more vulnerable to the associated adverse effects. [ 19 20 ] In Saudi Arabia, both nonprescribed and prescribed NSAIDs can be bought from the pharmacy without a prescription or healthcare instructions in most cases. This issue raises the concern of whether patients in Saudi Arabia have any basic knowledge about the safe usage and side effects of NSAIDs.…”

Section: Introductionmentioning

confidence: 99%

Knowledge of patients on safe medication use in relation to nonsteroidal anti-inflammatory drugs

et al. 2019

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“…The side effects of NSAIDs most commonly include gastrointestinal problems, hepatotoxicity and nephrotoxicity (17).…”

Section: Introductionmentioning

confidence: 99%

Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents

Zhuang

et al. 2017

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Abstract. Nefopam, an analgesic drug, effectively elicits antinociception in the majority of noxious and thermal models in rodents. Acetaminophen is among the most commonly used analgesic and antipyretic drugs worldwide, either on prescription or over the counter. The present study aimed to investigate the analgesic activity of nefopam combined with acetaminophen, which was expected to maximize the potency of analgesia and decrease the dose of nefopam required. Three series of experiments, namely acetic acid-induced writhing tests in mice, hot plate tests in mice and tail flick tests in rats, were used to evaluate the analgesic effect. Initially, an optimum proportion of the two drugs, 3.5 mg/kg nefopam (N) + 60 mg/kg acetaminophen (A), was determined by orthogonal array design based on writhing response number. Subsequently, combinations of N and A (1.75 N + 30 A, 3.5 N + 60 A and 7.0 N + 120 A mg/kg) were determined to elicit antinociception in the writhing test (P<0.01 vs. normal saline control) in a dose-dependent manner. In the hot plate test, hot plate latencies up to 60 min after drug treatment were observed. The combination of 7.0 N + 120 A mg/kg exerted a greater cumulative antinociceptive effect throughout the observation period, with an area under the curve value of 1,156.95±199.30 area units (AU), compared with that achieved by 7.0 N mg/kg alone (632.12±62.38 AU). Furthermore, both monotherapy and compound therapy exhibited antinociception dose-dependently in the tail-flick test. However, a combination of 5.0 N + 84 A mg/kg exerted greater analgesic effect compared with 5.0 N mg/kg alone. The data obtained demonstrate that acetaminophen may enhance the antinociceptive activity of nefopam. Thus, coadministration of nefopam with acetaminophen warrants clinical evaluation.

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