Tissue Eosinophilia in Hypersensitivity Reactions as revealed by the Human Skin Window

Effects of Corticosteroids on Eosinophil Chemotaxis and Adherence

“…The adherence of eosinophils in whole blood was significantly (P < 0.001) depressed 4 h after oral administration of 40 mg of prednisone. This effect was transient, however, as evidenced by the fact that adherence was normal at 24 and 48 h (Fig. 6).…”

“…Corticosteroids have been known for many years to induce peripheral eosinopenia (23) and have also been shown to reduce the local accumulation of eosinophils at sites of immediate hypersensitivity reactions as measured by skin window (24)(25)(26)(27)(28) and dermal biopsy (29) techniques. Nonetheless, the mechanism(s) of corticosteroid-induced eosinopenia and reduced tissue accumulation remains uncertain.…”

Effects of Corticosteroids on Eosinophil Chemotaxis and Adherence

“…The adherence of eosinophils in whole blood was significantly (P < 0.001) depressed 4 h after oral administration of 40 mg of prednisone. This effect was transient, however, as evidenced by the fact that adherence was normal at 24 and 48 h (Fig. 6).…”

“…Corticosteroids have been known for many years to induce peripheral eosinopenia (23) and have also been shown to reduce the local accumulation of eosinophils at sites of immediate hypersensitivity reactions as measured by skin window (24)(25)(26)(27)(28) and dermal biopsy (29) techniques. Nonetheless, the mechanism(s) of corticosteroid-induced eosinopenia and reduced tissue accumulation remains uncertain.…”

Mast Cells, Tissue Histamine and Eosinophils in Early- and Late-Phase Skin Reactions: Effects of a Single Dose of Prednisolone

“…The vascular endothelium must therefore also be involved in the process leading to the final increase in tissue eosinophil density. The number of circulating eosinophils is thought to re present a migratory phase from their origin in the bone marrow to their site of senescence or utilization in various tissues [14], Previously, the accumulation of eosinophils has been specifically attributed to the late-phase response, as pointed out above, and several investigators have noted an increase in eosino phil density during the late phase using skin window or dermal biopsy techniques [15][16][17][18]. We observed that these cells appeared in the 6-hour biopsies in all subjects regardless of whether they had a visual latephase response or not.…”

Anti‐IgE‐ and anti‐IgA‐induced eosinophil migration in atopics and healthy volunteers

“…The recruitment of eosinophils after antigen challenge in atopie subjects was described by Eidinger et al [31] some 30 years ago on the dermis. Since then, the phenomenon has been confirmed several times in different sites using different techniques [32][33][34][35][36][37].…”

Effects of Corticosteroids on Eosinophil Chemotaxis and Adherence

“…The adherence of eosinophils in whole blood was significantly (P < 0.001) depressed 4 h after oral administration of 40 mg of prednisone. This effect was transient, however, as evidenced by the fact that adherence was normal at 24 and 48 h (Fig. 6).…”

“…Corticosteroids have been known for many years to induce peripheral eosinopenia (23) and have also been shown to reduce the local accumulation of eosinophils at sites of immediate hypersensitivity reactions as measured by skin window (24)(25)(26)(27)(28) and dermal biopsy (29) techniques. Nonetheless, the mechanism(s) of corticosteroid-induced eosinopenia and reduced tissue accumulation remains uncertain.…”

Mast Cells, Tissue Histamine and Eosinophils in Early- and Late-Phase Skin Reactions: Effects of a Single Dose of Prednisolone

“…The vascular endothelium must therefore also be involved in the process leading to the final increase in tissue eosinophil density. The number of circulating eosinophils is thought to re present a migratory phase from their origin in the bone marrow to their site of senescence or utilization in various tissues [14], Previously, the accumulation of eosinophils has been specifically attributed to the late-phase response, as pointed out above, and several investigators have noted an increase in eosino phil density during the late phase using skin window or dermal biopsy techniques [15][16][17][18]. We observed that these cells appeared in the 6-hour biopsies in all subjects regardless of whether they had a visual latephase response or not.…”

Anti‐IgE‐ and anti‐IgA‐induced eosinophil migration in atopics and healthy volunteers

“…The recruitment of eosinophils after antigen challenge in atopie subjects was described by Eidinger et al [31] some 30 years ago on the dermis. Since then, the phenomenon has been confirmed several times in different sites using different techniques [32][33][34][35][36][37].…”

Effects of Corticosteroids on Eosinophil Chemotaxis and Adherence

“…The adherence of eosinophils in whole blood was significantly (P < 0.001) depressed 4 h after oral administration of 40 mg of prednisone. This effect was transient, however, as evidenced by the fact that adherence was normal at 24 and 48 h (Fig. 6).…”

“…Corticosteroids have been known for many years to induce peripheral eosinopenia (23) and have also been shown to reduce the local accumulation of eosinophils at sites of immediate hypersensitivity reactions as measured by skin window (24)(25)(26)(27)(28) and dermal biopsy (29) techniques. Nonetheless, the mechanism(s) of corticosteroid-induced eosinopenia and reduced tissue accumulation remains uncertain.…”

Mast Cells, Tissue Histamine and Eosinophils in Early- and Late-Phase Skin Reactions: Effects of a Single Dose of Prednisolone

“…The vascular endothelium must therefore also be involved in the process leading to the final increase in tissue eosinophil density. The number of circulating eosinophils is thought to re present a migratory phase from their origin in the bone marrow to their site of senescence or utilization in various tissues [14], Previously, the accumulation of eosinophils has been specifically attributed to the late-phase response, as pointed out above, and several investigators have noted an increase in eosino phil density during the late phase using skin window or dermal biopsy techniques [15][16][17][18]. We observed that these cells appeared in the 6-hour biopsies in all subjects regardless of whether they had a visual latephase response or not.…”

Anti‐IgE‐ and anti‐IgA‐induced eosinophil migration in atopics and healthy volunteers

“…The recruitment of eosinophils after antigen challenge in atopie subjects was described by Eidinger et al [31] some 30 years ago on the dermis. Since then, the phenomenon has been confirmed several times in different sites using different techniques [32][33][34][35][36][37].…”