The research examined the impact of moderation and mediation of political skill on organizational politics and job satisfaction. It applied a quantitative method. The population was 240 employees from the middle to top management in local government offices. With purposive sampling, 86 respondents working in the Regional Government Work Unit of Ternate City were involved in the survey. The research used a hierarchical regression analysis as a statistical analysis and IBM SPSS statistics Version 24. The results show that political skill strengthens the relationship between organizational politics and job satisfaction. Then, political skill also fully mediates the relationship between organizational politics and job satisfaction.