Nutrition and Cancer
 2024
DOI: 10.1080/01635581.2024.2361964
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The Complex Connection between Obesity and Cancer: Signaling Pathways and Therapeutic Implications

Mohamed El‐Tanani
1
,
Syed Arman Rabbani
2
,
Alaa A. A. Aljabali
3
et al.
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Cited by 5 publications

(2 citation statements)
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“…Additionally, obesity elevates the risk of developing pancreatic precancerous lesions [ 119 ]. Preclinical studies suggest several mechanisms by which obesity promotes pancreatic tumorigenesis, including hyperinsulinaemia and insulin resistance, hyperglycaemia, inflammation, altered cellular metabolism, hormone dysregulation, cellular stress, microbial dysbiosis, as well as activation of oncogenic drivers [ 120 , 121 , 122 ] ( Figure 4 A).…”
Section: Risk Factor: Obesitymentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Additionally, obesity elevates the risk of developing pancreatic precancerous lesions [ 119 ]. Preclinical studies suggest several mechanisms by which obesity promotes pancreatic tumorigenesis, including hyperinsulinaemia and insulin resistance, hyperglycaemia, inflammation, altered cellular metabolism, hormone dysregulation, cellular stress, microbial dysbiosis, as well as activation of oncogenic drivers [ 120 , 121 , 122 ] ( Figure 4 A).…”
Section: Risk Factor: Obesitymentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Obesity leads to activation of multiple oncogenic pathways associated with metabolic dysfunction ( 7 , 173 , 174 ). Cancer cells activate numerous oncogenic pathways to facilitate survival (evasion of apoptosis), growth through proliferation pathways driving the cell cycle and division, and metastasis through loss of cell adhesion, increased motility, and migration capacity through activation of the epithelial to mesenchymal transition pathways.…”
Section: Biomarkers Measured In Metabolic Dysregulation and Cancer Riskmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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