Steroid myopathy in connective tissue disease

Muscle metabolites, detected in urine by proton spectroscopy, correlate with disease damage in juvenile idiopathic inflammatory myopathies

“…Elevated urinary Cr:Cn ratios have been reported in adults with DM and PM (19,23). Although it has been suggested that elevated Cr:Cn ratios reflect a steroid-induced myopathy (23), we have previously found no evidence to support this suggestion in adults (19).…”

Muscle metabolites, detected in urine by proton spectroscopy, correlate with disease damage in juvenile idiopathic inflammatory myopathies

“…Elevated urinary Cr:Cn ratios have been reported in adults with DM and PM (19,23). Although it has been suggested that elevated Cr:Cn ratios reflect a steroid-induced myopathy (23), we have previously found no evidence to support this suggestion in adults (19).…”

Creatine supplementation attenuates corticosteroid-induced muscle wasting and impairment of exercise performance in rats

“…The histochemical evidence of diaphragmatic steroidal myopathy was absent, but this result may reflect the small number of muscles available for analysis. The present findings are not unexpected, since the catabolic effects of CS on body and muscle metabolism are well recognized (2,21). The mechanisms associated with the development of CS-induced atrophy are not completely known, but elevations of glutamine synthase activity and reduction of intracellular glutamine levels appear to play an important role in this process (23,25).…”

3. Aldolase

“…excretion has been reported to increase in cases of steroid-induced myopathy [6], but this analysis was not obtained in this case. The statin therapy was discontinued and the steroid therapy was tapered to the patient's previous maintenance dose.…”

Muscle metabolites, detected in urine by proton spectroscopy, correlate with disease damage in juvenile idiopathic inflammatory myopathies

“…Elevated urinary Cr:Cn ratios have been reported in adults with DM and PM (19,23). Although it has been suggested that elevated Cr:Cn ratios reflect a steroid-induced myopathy (23), we have previously found no evidence to support this suggestion in adults (19).…”

Creatine supplementation attenuates corticosteroid-induced muscle wasting and impairment of exercise performance in rats

“…The histochemical evidence of diaphragmatic steroidal myopathy was absent, but this result may reflect the small number of muscles available for analysis. The present findings are not unexpected, since the catabolic effects of CS on body and muscle metabolism are well recognized (2,21). The mechanisms associated with the development of CS-induced atrophy are not completely known, but elevations of glutamine synthase activity and reduction of intracellular glutamine levels appear to play an important role in this process (23,25).…”

3. Aldolase

“…excretion has been reported to increase in cases of steroid-induced myopathy [6], but this analysis was not obtained in this case. The statin therapy was discontinued and the steroid therapy was tapered to the patient's previous maintenance dose.…”

Muscle metabolites, detected in urine by proton spectroscopy, correlate with disease damage in juvenile idiopathic inflammatory myopathies

“…Elevated urinary Cr:Cn ratios have been reported in adults with DM and PM (19,23). Although it has been suggested that elevated Cr:Cn ratios reflect a steroid-induced myopathy (23), we have previously found no evidence to support this suggestion in adults (19).…”

Creatine supplementation attenuates corticosteroid-induced muscle wasting and impairment of exercise performance in rats

“…The histochemical evidence of diaphragmatic steroidal myopathy was absent, but this result may reflect the small number of muscles available for analysis. The present findings are not unexpected, since the catabolic effects of CS on body and muscle metabolism are well recognized (2,21). The mechanisms associated with the development of CS-induced atrophy are not completely known, but elevations of glutamine synthase activity and reduction of intracellular glutamine levels appear to play an important role in this process (23,25).…”

3. Aldolase

“…excretion has been reported to increase in cases of steroid-induced myopathy [6], but this analysis was not obtained in this case. The statin therapy was discontinued and the steroid therapy was tapered to the patient's previous maintenance dose.…”