Sensitive Electron-Capture GLC Determination of Metoclopramide in Biological Fluids

The pharmacokinetics of a new benzamide drug, clebopride, in the rat and the dog

“…In both species, however, the clebopride data are pharmacokinetically better described when an initial distributive phase(half-life 12-1 8 min) is considered (Table 1). The use of a two compartments open model to describe the pharmacokinetics of metoclopramide in the rat has been suggested by other authors (Tufion et al 1974;Tam & Axelson 1978). The figures for the volumes of distribution cited above should therefore be cautiously taken into account in their absolute value.…”

The pharmacokinetics of a new benzamide drug, clebopride, in the rat and the dog

“…In both species, however, the clebopride data are pharmacokinetically better described when an initial distributive phase(half-life 12-1 8 min) is considered (Table 1). The use of a two compartments open model to describe the pharmacokinetics of metoclopramide in the rat has been suggested by other authors (Tufion et al 1974;Tam & Axelson 1978). The figures for the volumes of distribution cited above should therefore be cautiously taken into account in their absolute value.…”

Individual and Simultaneous Spectrophotometric Determination of Dapsone and Metoclopramide HCl in Pharmaceutical Dosage Forms and Synthetic Binary Mixtures

“…3) Oral MCP may also be used to prevent nausea and vomiting caused by other medications. Moreover, MCP may be used in the fields of surgery, gynecology, cardiology and radiology.Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, 4-7) electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry.…”

“…Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, [4][5][6][7] electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry.…”

The pharmacokinetics of a new benzamide drug, clebopride, in the rat and the dog

“…In both species, however, the clebopride data are pharmacokinetically better described when an initial distributive phase(half-life 12-1 8 min) is considered (Table 1). The use of a two compartments open model to describe the pharmacokinetics of metoclopramide in the rat has been suggested by other authors (Tufion et al 1974;Tam & Axelson 1978). The figures for the volumes of distribution cited above should therefore be cautiously taken into account in their absolute value.…”

Individual and Simultaneous Spectrophotometric Determination of Dapsone and Metoclopramide HCl in Pharmaceutical Dosage Forms and Synthetic Binary Mixtures

“…3) Oral MCP may also be used to prevent nausea and vomiting caused by other medications. Moreover, MCP may be used in the fields of surgery, gynecology, cardiology and radiology.Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, 4-7) electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry.…”

“…Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, [4][5][6][7] electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry.…”

The pharmacokinetics of a new benzamide drug, clebopride, in the rat and the dog

“…In both species, however, the clebopride data are pharmacokinetically better described when an initial distributive phase(half-life 12-1 8 min) is considered (Table 1). The use of a two compartments open model to describe the pharmacokinetics of metoclopramide in the rat has been suggested by other authors (Tufion et al 1974;Tam & Axelson 1978). The figures for the volumes of distribution cited above should therefore be cautiously taken into account in their absolute value.…”

Individual and Simultaneous Spectrophotometric Determination of Dapsone and Metoclopramide HCl in Pharmaceutical Dosage Forms and Synthetic Binary Mixtures

“…3) Oral MCP may also be used to prevent nausea and vomiting caused by other medications. Moreover, MCP may be used in the fields of surgery, gynecology, cardiology and radiology.Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, 4-7) electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry.…”

“…Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, [4][5][6][7] electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry.…”