Safety of apraclonidine eye drops in diagnosis of Horner syndrome in an outpatient pediatric ophthalmology clinic

Eldib, Amgad; Patil, Preeti A.; Nischal, Ken K.; Mitchell, Ellen R.; Hiasat, Jamila G.; Pihlblad, Matthew S.

doi:10.1016/j.jaapos.2021.07.011

Cited by 2 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Horner syndrome, the affected pupil and the tarsal muscle experience denervation hypersensitivity. Apraclonidine, an alpha-2 adrenergic agonist with weak alpha-1 adrenergic agonist activity, when applied topically, induces dilation of the affected pupil and potentially elevates the lid, while leaving the normal pupil unchanged [ 11 ]. Horner syndrome predominantly arises as an acquired condition, often stemming from systemic or local diseases or iatrogenic causes.…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Guillain-Barré Syndrome With Associated Horner Syndrome: A Case Report

Irfan,

Ganesan,

Jain

et al. 2024

Cureus

View full text Add to dashboard Cite

Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy involving the peripheral nervous system. Autonomic dysfunctions are well-known complications of GBS and are major contributors to mortality. Autonomic dysfunctions are classically described during the acute phase of illness. In the literature, Horner syndrome as a manifestation of GBS has been reported in very few cases. Here, we describe a case of GBS with an acute presentation of flaccid paraparesis associated with unilateral Horner syndrome. Detecting the cause of acute flaccid paraparesis with unilateral Horner syndrome poses a diagnostic challenge, making it crucial for clinicians to maintain a heightened awareness for distinguishing between GBS and its variants, as well as other potential mimics.

show abstract

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Guillain-Barré Syndrome With Associated Horner Syndrome: A Case Report

Irfan,

Ganesan,

Jain

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“… 34 A more recent retrospective study including 46 pediatric patients, 17 of whom were aged under 6 months, who were all tested with topical 0.5% apraclonidine to confirm HS, reported the absence of any documented adverse effects. 35 Nonetheless, it is advisable to avoid this test in young infants. When used, the patients should be observed for at least 2 hours after instillation.…”

Section: Neuro-ophthalmological Manifestations and Diagnosis Of Horne...mentioning

confidence: 99%

Neuro-Ophthalmological Manifestations of Horner’s Syndrome: Current Perspectives

Maamouri,

Ferchichi,

Houmane

et al. 2023

View full text Add to dashboard Cite

Horner’s syndrome (HS) is caused by a damage to the oculosympathetic pathway. HS may be congenital, but it is usually acquired and may reveal a life-threatening condition. According to the anatomic location of the underlying pathologic process, HS is classified as central, pre- or postganglionic, when the lesion affects the first, second or third-order neuron, respectively. Pharmacological testing, if available, can be used to differentiate HS from « pseudo-HS » in patients with mild symptoms. Given the financial burden that imaging of the entire oculosympathetic pathway represents, a targeted imaging approach is advised. Although in the majority of cases, clinical examination may predict etiology, in other cases pharmacological testing can help in the localization process. We searched PubMed data base for papers published before December 2022 that concerned Horner’s syndrome, its neuro-ophthalmological manifestations and diagnosis. In this article, we describe the main neuro-ophthalmological manifestations of the three types of HS, the most common etiologies, and a targeted diagnostic strategy in each type.

show abstract

Safety of apraclonidine eye drops in diagnosis of Horner syndrome in an outpatient pediatric ophthalmology clinic

Cited by 2 publications

References 16 publications

A Rare Presentation of Guillain-Barré Syndrome With Associated Horner Syndrome: A Case Report

A Rare Presentation of Guillain-Barré Syndrome With Associated Horner Syndrome: A Case Report

Neuro-Ophthalmological Manifestations of Horner’s Syndrome: Current Perspectives

Contact Info

Product

Resources

About