Procedures Used at Stateville Penitentiary for the Testing of Potential Antimalarial Agents 1

The Therapeutic Effectiveness of Large Doses of Paludrine in Acute Attacks of Sporozoite-Induced Viv Ax Malaria (Chesson Strain) 1

“…Three subjects complained of mild transient abdominal discomfort during the first few days of therapy, and one subject .complained of slight blurring of vision on occasions. No other subjective or objective evidence of toxicity was demonstrated by routine studies for drug toxicity (7). (Table I).…”

The Therapeutic Effectiveness of Large Doses of Paludrine in Acute Attacks of Sporozoite-Induced Viv Ax Malaria (Chesson Strain) 1

“…Three subjects complained of mild transient abdominal discomfort during the first few days of therapy, and one subject .complained of slight blurring of vision on occasions. No other subjective or objective evidence of toxicity was demonstrated by routine studies for drug toxicity (7). (Table I).…”

Spatial distribution of G6PD deficiency variants across malaria-endemic regions

“…The G6PDd phenotype has long been considered homogenous across African populations, with much of the pre-molecular era literature reporting G6PD A- from electrophoresis assays across the continent [ 34 ]. The early investigations of “primaquine sensitivity” among G6PD A- volunteers found primaquine-induced haemolysis to be mild and self-limiting [ 1 , 30 , 64 , 67 - 69 ]. Nevertheless, the haemolytic susceptibility of this “mild” variant has been observed through severe reactions requiring transfusion [ 70 ], as well as through the failure of the Lapdap (chlorproguanil-dapsone) anti-malarial trials [ 71 , 72 ], and as haemolysis induced by the ingestion of fava beans [ 73 ], a pathology previously thought to only be triggered by more severe variants [ 74 ].…”

The Clinical Trial of Eighteen Analogues of Pamaquin (Plasmochin) in Viv Ax Malaria (Chesson Strain) 1

“…Details of the general procedure and the plan of observation are reported elsewhere (11 quadrimaculatus mosquitoes. This strain is characterized by a high relapse rate when treated with non-curative drugs such as quinine and quinacrine, by a short period of latency between successive attacks, and by almost complete absence of delayed primary attacks (13,14).…”

The Therapeutic Effectiveness of Large Doses of Paludrine in Acute Attacks of Sporozoite-Induced Viv Ax Malaria (Chesson Strain) 1

“…Three subjects complained of mild transient abdominal discomfort during the first few days of therapy, and one subject .complained of slight blurring of vision on occasions. No other subjective or objective evidence of toxicity was demonstrated by routine studies for drug toxicity (7). (Table I).…”

Spatial distribution of G6PD deficiency variants across malaria-endemic regions

“…The G6PDd phenotype has long been considered homogenous across African populations, with much of the pre-molecular era literature reporting G6PD A- from electrophoresis assays across the continent [ 34 ]. The early investigations of “primaquine sensitivity” among G6PD A- volunteers found primaquine-induced haemolysis to be mild and self-limiting [ 1 , 30 , 64 , 67 - 69 ]. Nevertheless, the haemolytic susceptibility of this “mild” variant has been observed through severe reactions requiring transfusion [ 70 ], as well as through the failure of the Lapdap (chlorproguanil-dapsone) anti-malarial trials [ 71 , 72 ], and as haemolysis induced by the ingestion of fava beans [ 73 ], a pathology previously thought to only be triggered by more severe variants [ 74 ].…”

The Clinical Trial of Eighteen Analogues of Pamaquin (Plasmochin) in Viv Ax Malaria (Chesson Strain) 1

“…Details of the general procedure and the plan of observation are reported elsewhere (11 quadrimaculatus mosquitoes. This strain is characterized by a high relapse rate when treated with non-curative drugs such as quinine and quinacrine, by a short period of latency between successive attacks, and by almost complete absence of delayed primary attacks (13,14).…”

The Therapeutic Effectiveness of Large Doses of Paludrine in Acute Attacks of Sporozoite-Induced Viv Ax Malaria (Chesson Strain) 1

“…Three subjects complained of mild transient abdominal discomfort during the first few days of therapy, and one subject .complained of slight blurring of vision on occasions. No other subjective or objective evidence of toxicity was demonstrated by routine studies for drug toxicity (7). (Table I).…”

Spatial distribution of G6PD deficiency variants across malaria-endemic regions

“…The G6PDd phenotype has long been considered homogenous across African populations, with much of the pre-molecular era literature reporting G6PD A- from electrophoresis assays across the continent [ 34 ]. The early investigations of “primaquine sensitivity” among G6PD A- volunteers found primaquine-induced haemolysis to be mild and self-limiting [ 1 , 30 , 64 , 67 - 69 ]. Nevertheless, the haemolytic susceptibility of this “mild” variant has been observed through severe reactions requiring transfusion [ 70 ], as well as through the failure of the Lapdap (chlorproguanil-dapsone) anti-malarial trials [ 71 , 72 ], and as haemolysis induced by the ingestion of fava beans [ 73 ], a pathology previously thought to only be triggered by more severe variants [ 74 ].…”

The Clinical Trial of Eighteen Analogues of Pamaquin (Plasmochin) in Viv Ax Malaria (Chesson Strain) 1

“…Details of the general procedure and the plan of observation are reported elsewhere (11 quadrimaculatus mosquitoes. This strain is characterized by a high relapse rate when treated with non-curative drugs such as quinine and quinacrine, by a short period of latency between successive attacks, and by almost complete absence of delayed primary attacks (13,14).…”