Procedures Used at Stateville Penitentiary for the Testing of Potential Antimalarial Agents 1

Alving, Alf S.; Craige, Branch; Pullman, Theodore N.; Whorton, C. Merrill; Eichelberger, Lillian

doi:10.1172/jci101956

Cited by 58 publications

(34 citation statements)

References 4 publications

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“…The drug was supplied 3 and used in the form of the monophosphate salt which is 75.5 per cent base. All dosages recorded in this paper are in terms of the base 1 Unit, Department of Medicine, the former group bred Anopheles quadrimaculatus mosquitoes, supervised their infection and the inoculation of volunteers, and determined the intensity of infection in the salivary glands of the mosquitoes.…”

Section: Introductionmentioning

confidence: 99%

Pentaquine (Sn-13,276), a Therapeutic Agent Effective in Reducing the Relapse Rate in Viv Ax Malaria 1

Alving¹,

Craige²,

Whorton³

et al. 1948

J. Clin. Invest.

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Section: Introductionmentioning

confidence: 99%

Pentaquine (Sn-13,276), a Therapeutic Agent Effective in Reducing the Relapse Rate in Viv Ax Malaria 1

Alving¹,

Craige²,

Whorton³

et al. 1948

J. Clin. Invest.

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“…Three subjects complained of mild transient abdominal discomfort during the first few days of therapy, and one subject .complained of slight blurring of vision on occasions. No other subjective or objective evidence of toxicity was demonstrated by routine studies for drug toxicity (7). (Table I).…”

Section: Resultsmentioning

confidence: 99%

The Therapeutic Effectiveness of Large Doses of Paludrine in Acute Attacks of Sporozoite-Induced Viv Ax Malaria (Chesson Strain) 1

Pullman¹,

Whorton²,

Craige³

et al. 1948

J. Clin. Invest.

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“…Details of the general procedure and the plan of observation are reported elsewhere (11 quadrimaculatus mosquitoes. This strain is characterized by a high relapse rate when treated with non-curative drugs such as quinine and quinacrine, by a short period of latency between successive attacks, and by almost complete absence of delayed primary attacks (13,14).…”

Section: Methods and Proceduresmentioning

confidence: 99%

The Clinical Trial of Eighteen Analogues of Pamaquin (Plasmochin) in Viv Ax Malaria (Chesson Strain) 1

Alving¹,

Pullman²,

Craige³

et al. 1948

J. Clin. Invest.

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In the malarial research program conducted on a national scale during World War II, several drugs were developed which had marked superiority over quinacrine (atabrine) and quinine in their ability to terminate individual attacks of vivax malaria (1). For example, chloroquine (SN-7618) in terms of oral dosage and the resulting plasma concentration can be administered in amounts many times that required to suppress the disease (2). The margin between the therapeutic and toxic dose of chloroquine is several times that which exists for quinine and quinacrine. When these new compounds, however, failed, even at high dosages, to affect the relapse rate it seemed doubtful that further extension of research aimed chiefly towards finding a more effective and less toxic, and primarily suppressive, drug would lead

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Procedures Used at Stateville Penitentiary for the Testing of Potential Antimalarial Agents 1

Cited by 58 publications

References 4 publications

Pentaquine (Sn-13,276), a Therapeutic Agent Effective in Reducing the Relapse Rate in Viv Ax Malaria 1

Pentaquine (Sn-13,276), a Therapeutic Agent Effective in Reducing the Relapse Rate in Viv Ax Malaria 1

The Therapeutic Effectiveness of Large Doses of Paludrine in Acute Attacks of Sporozoite-Induced Viv Ax Malaria (Chesson Strain) 1

The Clinical Trial of Eighteen Analogues of Pamaquin (Plasmochin) in Viv Ax Malaria (Chesson Strain) 1

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