Potential of ‘Omics’ Technologies for Implementation in Research on Phytotherapeutical Toxicology

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

“…The toxicity of medicinal plants and natural products is strictly associated to the presence of bioactive metabolites in the plant substantial and their toxic potential ( Woo et al, 2012 ). The issue becomes considerably more intricate when considering complex, heterogeneous botanical drugs mix which can cause unpredictable effects ( Efferth et al, 2012 ). Many natural products have hepatotoxic, carcinogenic, cytotoxic, genotoxic, phototoxic, possible pulmonary toxicity, embryotoxic, and neurotoxic effects ( Wang et al, 2021 ).…”

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

“…The toxicity of medicinal plants and natural products is strictly associated to the presence of bioactive metabolites in the plant substantial and their toxic potential ( Woo et al, 2012 ). The issue becomes considerably more intricate when considering complex, heterogeneous botanical drugs mix which can cause unpredictable effects ( Efferth et al, 2012 ). Many natural products have hepatotoxic, carcinogenic, cytotoxic, genotoxic, phototoxic, possible pulmonary toxicity, embryotoxic, and neurotoxic effects ( Wang et al, 2021 ).…”

Incorporation of chemical and toxicological availability into metal mixture toxicity modeling: State of the art and future perspectives

“…Covalent modifications and various interactive effects (e.g., cell-cell, protein-protein and protein-ligand) are responsible for this variability. The proteome is dynamic due to changeable protein functions resulting from such modifications (Efferth & Greten, 2012). Protein expression levels are the product of the process of protein transcription, translation and degradation within cells, including the different stages of maturation and modification within transcripts and proteins.…”

From Bioreactor to Entire Plants

“…Briefly, the discovery process of a new active chemical entity from plants is illustrated by anticancer drug research. Nowadays, omics methods for assessing the toxicity of plant extracts can also be used for the targeted discovery of new activities (Efferth & Greten, 2012;Ouedraogo et al, 2012;Pelkonen et al, 2012). Compared to the research of new biological activities through Blindfold strategies, the use of an ethnobotanical approach appears efficient (Ningthoujam et al, 2012).…”

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

“…The toxicity of medicinal plants and natural products is strictly associated to the presence of bioactive metabolites in the plant substantial and their toxic potential ( Woo et al, 2012 ). The issue becomes considerably more intricate when considering complex, heterogeneous botanical drugs mix which can cause unpredictable effects ( Efferth et al, 2012 ). Many natural products have hepatotoxic, carcinogenic, cytotoxic, genotoxic, phototoxic, possible pulmonary toxicity, embryotoxic, and neurotoxic effects ( Wang et al, 2021 ).…”

Incorporation of chemical and toxicological availability into metal mixture toxicity modeling: State of the art and future perspectives

“…Covalent modifications and various interactive effects (e.g., cell-cell, protein-protein and protein-ligand) are responsible for this variability. The proteome is dynamic due to changeable protein functions resulting from such modifications (Efferth & Greten, 2012). Protein expression levels are the product of the process of protein transcription, translation and degradation within cells, including the different stages of maturation and modification within transcripts and proteins.…”

From Bioreactor to Entire Plants

“…Briefly, the discovery process of a new active chemical entity from plants is illustrated by anticancer drug research. Nowadays, omics methods for assessing the toxicity of plant extracts can also be used for the targeted discovery of new activities (Efferth & Greten, 2012;Ouedraogo et al, 2012;Pelkonen et al, 2012). Compared to the research of new biological activities through Blindfold strategies, the use of an ethnobotanical approach appears efficient (Ningthoujam et al, 2012).…”

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

“…The toxicity of medicinal plants and natural products is strictly associated to the presence of bioactive metabolites in the plant substantial and their toxic potential ( Woo et al, 2012 ). The issue becomes considerably more intricate when considering complex, heterogeneous botanical drugs mix which can cause unpredictable effects ( Efferth et al, 2012 ). Many natural products have hepatotoxic, carcinogenic, cytotoxic, genotoxic, phototoxic, possible pulmonary toxicity, embryotoxic, and neurotoxic effects ( Wang et al, 2021 ).…”

Incorporation of chemical and toxicological availability into metal mixture toxicity modeling: State of the art and future perspectives

“…Covalent modifications and various interactive effects (e.g., cell-cell, protein-protein and protein-ligand) are responsible for this variability. The proteome is dynamic due to changeable protein functions resulting from such modifications (Efferth & Greten, 2012). Protein expression levels are the product of the process of protein transcription, translation and degradation within cells, including the different stages of maturation and modification within transcripts and proteins.…”

From Bioreactor to Entire Plants

“…Briefly, the discovery process of a new active chemical entity from plants is illustrated by anticancer drug research. Nowadays, omics methods for assessing the toxicity of plant extracts can also be used for the targeted discovery of new activities (Efferth & Greten, 2012;Ouedraogo et al, 2012;Pelkonen et al, 2012). Compared to the research of new biological activities through Blindfold strategies, the use of an ethnobotanical approach appears efficient (Ningthoujam et al, 2012).…”