Potential of ‘Omics’ Technologies for Implementation in Research on Phytotherapeutical Toxicology

Efferth, Thomas; Greten, Henry Johannes

doi:10.1016/b978-0-12-394591-4.00007-6

Cited by 5 publications

(3 citation statements)

References 32 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The toxicity of medicinal plants and natural products is strictly associated to the presence of bioactive metabolites in the plant substantial and their toxic potential ( Woo et al, 2012 ). The issue becomes considerably more intricate when considering complex, heterogeneous botanical drugs mix which can cause unpredictable effects ( Efferth et al, 2012 ). Many natural products have hepatotoxic, carcinogenic, cytotoxic, genotoxic, phototoxic, possible pulmonary toxicity, embryotoxic, and neurotoxic effects ( Wang et al, 2021 ).…”

Section: Effect Of Natural Products On Gut-x Axis (Pharmacology Toxic...mentioning

confidence: 99%

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

Li,

Wang,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Introduction: The gastrointestinal tract is integral to defending against external contaminants, featuring a complex array of immunological, physical, chemical, and microbial barriers. Mycotoxins, which are toxic metabolites from fungi, are pervasive in both animal feed and human food, presenting substantial health risks.Methods: This review examines the pharmacological, toxicological, and microbiological impacts of natural products on mycotoxicosis, with a particular focus on the gut-x axis. The analysis synthesizes current understanding and explores the role of natural products rich in polysaccharides, polyphenols, flavonoids, and saponins. Results: The review highlights that mycotoxins can disrupt intestinal integrity, alter inflammatory responses, damage the mucus layer, and disturb the bacterial balance. The toxins' effects are extensive, potentially harming the immune system, liver, kidneys, and skin, and are associated with serious conditions such as cancer, hormonal changes, genetic mutations, bleeding, birth defects, and neurological issues. Natural products have shown potential anticancer, anti-tumor, antioxidant, immunomodulatory, and antitoxic properties.Discussion: The review underscores the emerging therapeutic strategy of targeting gut microbial modulation. It identifies knowledge gaps and suggests future research directions to deepen our understanding of natural products' role in gut-x axis health and to mitigate the global health impact of mycotoxin-induced diseases.

show abstract

Section: Effect Of Natural Products On Gut-x Axis (Pharmacology Toxic...mentioning

confidence: 99%

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

Li,

Wang,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Covalent modifications and various interactive effects (e.g., cell-cell, protein-protein and protein-ligand) are responsible for this variability. The proteome is dynamic due to changeable protein functions resulting from such modifications (Efferth & Greten, 2012). Protein expression levels are the product of the process of protein transcription, translation and degradation within cells, including the different stages of maturation and modification within transcripts and proteins.…”

Section: Omics-based Approachmentioning

confidence: 99%

Incorporation of chemical and toxicological availability into metal mixture toxicity modeling: State of the art and future perspectives

Gong

Qiu

Romero‐Freire

et al. 2020

Critical Reviews in Environmental Science and Technology

View full text Add to dashboard Cite

General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

show abstract

“…Briefly, the discovery process of a new active chemical entity from plants is illustrated by anticancer drug research. Nowadays, omics methods for assessing the toxicity of plant extracts can also be used for the targeted discovery of new activities (Efferth & Greten, 2012;Ouedraogo et al, 2012;Pelkonen et al, 2012). Compared to the research of new biological activities through Blindfold strategies, the use of an ethnobotanical approach appears efficient (Ningthoujam et al, 2012).…”

Section: General Strategies To Produce Secondary Metabolites From Plamentioning

confidence: 99%

From Bioreactor to Entire Plants

Nguyen¹,

Dauwe²,

Bourgaud³

et al. 2013

New Light on Alkaloid Biosynthesis and Future Prospects

View full text Add to dashboard Cite

Potential of ‘Omics’ Technologies for Implementation in Research on Phytotherapeutical Toxicology

Cited by 5 publications

References 32 publications

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

Incorporation of chemical and toxicological availability into metal mixture toxicity modeling: State of the art and future perspectives

From Bioreactor to Entire Plants

Contact Info

Product

Resources

About