Photochemical sample treatment for extracts clean up in PCB analysis from sediments

Abstract

Sample purification can be considered the most polluting step of the whole analytical process for PCBs determination in sediment samples. The use of photochemical sample treatment represents an alternative methodology for extracts clean up allowing for a reduction of the used amount of organic solvents. The first application of a photochemical sample treatment for the selective removal or reduction of organic substances interfering with PCBs analyses in sediments is reported. The method's efficiency and robustness were compared with currently used chromatographic purification. Quality parameters such as recovery, linearity and reproducibility were studied. The entire procedure was validated by four replicate analysis of certified reference sediment. The quantification limits (LOQ) obtained by us ranged from 1 to 3.1 ng g(-1). The RSD for each congener was below 15% and recoveries were in the range 40-130%. Results based on the analysis of real and certified samples showed similar or improved detection thresholds and pointed out the advantages of the photochemical methodology in terms of costs and environmental friendly conditions.

Determination of selected phthalates by gas chromatography–mass spectrometry in mural paintings from Palermo (Italy)

“…Moreover DEHP is a recognized testicular toxicant, altering the normal functions of Sertoli and Leydig cells by affecting spermatogenesis and testosterone production in rats [5], in fact, phthalates are classified in the EU as category 2 substances to reproduction and as 1B in the Globally Harmonized System of Classification System and Labeling of Chemicals (GHS). Other studies [38] argue that high doses of DEHP induced liver and kidney damage, testicular toxicity, and endocrine disorders in androgen production. In humans, the reported health effects of DEHP are altered semen quality, reproductive and developmental effects, and endocrine disruption, which have recently caused much public concern [39].…”

Determination of selected phthalates by gas chromatography–mass spectrometry in mural paintings from Palermo (Italy)

“…Moreover DEHP is a recognized testicular toxicant, altering the normal functions of Sertoli and Leydig cells by affecting spermatogenesis and testosterone production in rats [5], in fact, phthalates are classified in the EU as category 2 substances to reproduction and as 1B in the Globally Harmonized System of Classification System and Labeling of Chemicals (GHS). Other studies [38] argue that high doses of DEHP induced liver and kidney damage, testicular toxicity, and endocrine disorders in androgen production. In humans, the reported health effects of DEHP are altered semen quality, reproductive and developmental effects, and endocrine disruption, which have recently caused much public concern [39].…”

Development and Validation of a Gas Chromatography–Mass Spectrometry Method for the Analysis of the Novel Plant-Based Substance with Antimicrobial Activity

“…The GC-MS analysis was validated in according with the EU Commission regulation guidelines [73,78,79], the European Pharmacopoeia 11.0 [71], the Russian Pharmacopoeia (XIV edition) [72], and ICH guidelines [80]. The parameters for validation of this analytical method were suitability of the chromatographic system, specificity, linearity, accuracy, and reproducibility.…”

Suitability of Short- and Long-Term Storage of Volatile Organic Compounds Samples in Syringe-Based Containers: A Comparison Study

“…The application of data validation approaches to chromatographic and spectrometric data plays a critical role in thoroughly assessing cause–effect systems [ 34 , 35 , 36 ] and thus allows both to assess the effects of syringe-based containers on VOC samples. This ultimately enhances the confidence and reliability of cause-–effect analyses in various scientific fields.…”

Determination of selected phthalates by gas chromatography–mass spectrometry in mural paintings from Palermo (Italy)

“…Moreover DEHP is a recognized testicular toxicant, altering the normal functions of Sertoli and Leydig cells by affecting spermatogenesis and testosterone production in rats [5], in fact, phthalates are classified in the EU as category 2 substances to reproduction and as 1B in the Globally Harmonized System of Classification System and Labeling of Chemicals (GHS). Other studies [38] argue that high doses of DEHP induced liver and kidney damage, testicular toxicity, and endocrine disorders in androgen production. In humans, the reported health effects of DEHP are altered semen quality, reproductive and developmental effects, and endocrine disruption, which have recently caused much public concern [39].…”

Development and Validation of a Gas Chromatography–Mass Spectrometry Method for the Analysis of the Novel Plant-Based Substance with Antimicrobial Activity

“…The GC-MS analysis was validated in according with the EU Commission regulation guidelines [73,78,79], the European Pharmacopoeia 11.0 [71], the Russian Pharmacopoeia (XIV edition) [72], and ICH guidelines [80]. The parameters for validation of this analytical method were suitability of the chromatographic system, specificity, linearity, accuracy, and reproducibility.…”

Suitability of Short- and Long-Term Storage of Volatile Organic Compounds Samples in Syringe-Based Containers: A Comparison Study

“…The application of data validation approaches to chromatographic and spectrometric data plays a critical role in thoroughly assessing cause–effect systems [ 34 , 35 , 36 ] and thus allows both to assess the effects of syringe-based containers on VOC samples. This ultimately enhances the confidence and reliability of cause-–effect analyses in various scientific fields.…”

Determination of selected phthalates by gas chromatography–mass spectrometry in mural paintings from Palermo (Italy)

“…Moreover DEHP is a recognized testicular toxicant, altering the normal functions of Sertoli and Leydig cells by affecting spermatogenesis and testosterone production in rats [5], in fact, phthalates are classified in the EU as category 2 substances to reproduction and as 1B in the Globally Harmonized System of Classification System and Labeling of Chemicals (GHS). Other studies [38] argue that high doses of DEHP induced liver and kidney damage, testicular toxicity, and endocrine disorders in androgen production. In humans, the reported health effects of DEHP are altered semen quality, reproductive and developmental effects, and endocrine disruption, which have recently caused much public concern [39].…”

Development and Validation of a Gas Chromatography–Mass Spectrometry Method for the Analysis of the Novel Plant-Based Substance with Antimicrobial Activity

“…The GC-MS analysis was validated in according with the EU Commission regulation guidelines [73,78,79], the European Pharmacopoeia 11.0 [71], the Russian Pharmacopoeia (XIV edition) [72], and ICH guidelines [80]. The parameters for validation of this analytical method were suitability of the chromatographic system, specificity, linearity, accuracy, and reproducibility.…”

Suitability of Short- and Long-Term Storage of Volatile Organic Compounds Samples in Syringe-Based Containers: A Comparison Study

“…The application of data validation approaches to chromatographic and spectrometric data plays a critical role in thoroughly assessing cause–effect systems [ 34 , 35 , 36 ] and thus allows both to assess the effects of syringe-based containers on VOC samples. This ultimately enhances the confidence and reliability of cause-–effect analyses in various scientific fields.…”