Peptide functionalized poly ethylene glycol-poly caprolactone nanomicelles for specific cabazitaxel delivery to metastatic breast cancer cells

Mahdaviani, Parvin; Bahadorikhalili, Saeed; Navaei-Nigjeh, Mona; Vafaei, Seyed Yaser; Esfandyari-Manesh, Mehdi; Abdolghaffari, Amir Hossein; Daman, Zahra; Atyabi, Fatemeh; Ghahremani, Mohammad Hossein; Amini, Mohsen; Lavasanifar, Afsaneh; Dinarvand, Rassoul

doi:10.1016/j.msec.2017.05.126

Cited by 31 publications

(29 citation statements)

References 30 publications

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“…The results on MCF-7 cell lines (Figure 7A,A′) demonstrated that the CBZ micellar solution has shown a 3.12-fold induction of apoptosis and 7.61-fold induction of necrosis, whereas the CBZ liposomes have shown an 8.22-fold induction of apoptosis and 5.95-fold induction of necrosis in comparison with control, which implies that the therapeutic potential of liposomes was more when compared to the CBZ micellar solution. CBZ NPs have shown a 30.78-fold induction of necrosis when compared to control; this result is in agreement with the previous reports in which the apoptotic potential of CBZ was analyzed [26].…”

Section: Resultssupporting

confidence: 92%

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Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects

et al. 2019

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Jevtana® is a micellar cabazitaxel (CBZ) solution that was approved for prostate cancer in 2010, and recently, this drug has been reported for breast cancer. The purpose of this study is to evaluate the mediated delivery of CBZ via liposomes and nanoparticles (NPs) for the treatment of breast cancer and compare these with a micellar formulation that is currently in clinical use. CBZ-loaded nanocarriers were prepared with particle sizes between 70–110 nm, and with the sustained in vitro release of CBZ for more than 28 days. Cytotoxicity studies on MCF-7 and MDA-MB-231 cells demonstrated the toxic potential of these nanocarriers. Cellular internalization revealed that NPs and liposomes have better permeability than micelles. Cell cycle analysis and apoptosis studies on MCF-7 and MDA-MB-231 cells confirmed G2/M phase arrest as well as cell death due to apoptosis and necrosis, where formulations were found to be effective compared to a micellar CBZ solution. Results from pharmacokinetic studies revealed that there is an increased circulation half-life and mean residence time for CBZ liposomes and NPs in comparison with a micellar CBZ solution. CBZ liposomes and NPs showed a reduction in hemolysis and neutropenia in comparison with a micellar CBZ solution in rats.

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Section: Resultssupporting

confidence: 92%

“…The size and surface morphology of liposomes and NPs were determined using transmission electron microscopy [26]. CBZ-loaded liposomes and NPs were deposited on copper grids pre-coated with carbon and dried for 5 to 10 min.…”

Section: Methodsmentioning

confidence: 99%

Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects

et al. 2019

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“…Polymeric drug delivery systems are promising carriers that provide efficacious approaches to improve the delivery of active pharmaceutical ingredients and alleviate the toxicity of pharmaceutical payloads through passive and active targeting methods [1][2][3][4][5]. Poly (D, L lactide-co-glycolide) (PLGA) is one of the most widely used biodegradable synthetic polymers for drug delivery [1,6].…”

Section: Introductionmentioning

confidence: 99%

Synthetic and biological identities of polymeric nanoparticles influencing the cellular delivery: An immunological link

Rezaei

Daghighi

Raoufi

et al. 2019

Journal of Colloid and Interface Science

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“…These are characteristic peaks of polysaccharides and have been identified in the spectra of xylene and glycan polysaccharides. The peak found at 3355 cm −1 is related to the tensile vibration of the O–H bond [ 96 , 97 ].…”

Section: Resultsmentioning

confidence: 99%

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

et al. 2022

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Today, cancer treatment is an important issue in the medical world due to the challenges and side effects of ongoing treatment procedures. Current methods can be replaced with targeted nano-drug delivery systems to overcome such side effects. In the present work, an intelligent nano-system consisting of Chitosan (Ch)/Gamma alumina (γAl)/Fe3O4 and 5-Fluorouracil (5-FU) was synthesized and designed for the first time in order to influence the Michigan Cancer Foundation-7 (MCF-7) cell line in the treatment of breast cancer. Physico-chemical characterization of the nanocarriers was carried out using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), dynamic light scattering (DLS), and scanning electron microscopy (SEM). SEM analysis revealed smooth and homogeneous spherical nanoparticles. The high stability of the nanoparticles and their narrow size distribution was confirmed by DLS. The results of the loading study demonstrated that these nano-systems cause controlled, stable, and pH-sensitive release in cancerous environments with an inactive targeting mechanism. Finally, the results of MTT and flow cytometry tests indicated that this nano-system increased the rate of apoptosis induction on cancerous masses and could be an effective alternative to current treatments.

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Peptide functionalized poly ethylene glycol-poly caprolactone nanomicelles for specific cabazitaxel delivery to metastatic breast cancer cells

Cited by 31 publications

References 30 publications

Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects

Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects

Synthetic and biological identities of polymeric nanoparticles influencing the cellular delivery: An immunological link

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

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