Peptide functionalized poly ethylene glycol-poly caprolactone nanomicelles for specific cabazitaxel delivery to metastatic breast cancer cells

Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects

“…The results on MCF-7 cell lines (Figure 7A,A′) demonstrated that the CBZ micellar solution has shown a 3.12-fold induction of apoptosis and 7.61-fold induction of necrosis, whereas the CBZ liposomes have shown an 8.22-fold induction of apoptosis and 5.95-fold induction of necrosis in comparison with control, which implies that the therapeutic potential of liposomes was more when compared to the CBZ micellar solution. CBZ NPs have shown a 30.78-fold induction of necrosis when compared to control; this result is in agreement with the previous reports in which the apoptotic potential of CBZ was analyzed [26].…”

Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review

“…After conjugation with a particular number of HER molecules, the worm-like structure of the micelles was preserved [42]. Meanwhile, the SEM image in the study showed that CBZ polymeric micelles had a uniform spherical morphology, with a particle size of around 100 nm and a small particle size range [38].…”

“…Compared to the control group, there was an overall increase in the percentages of early and late apoptotic MCF-7 cells, although this increase was practically the same in the targeted and non-targeted groups. However, treatment with the targeted copolymeric micelles demonstrated better apoptosis and necrosis induction than the non-targeted copolymeric micelles for the MDA-MB-231 cell line [38].…”

“…Further discussion of the developed themes is presented in this section. Except for Mahdaviani et al [38], who utilised N-protected-3-aminopropan-1-ol as the initiator for the ROP of ε-CL to PCL, the synthesis process of PCL-PEG copolymers of other studies was done using PEG as the initiator in the presence of stannous octoate as the catalyst [35][36][37][39][40][41]. The reaction had to be conducted at 110 • C to ensure complete conversion of ε-CL to PCL.…”

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

“…These are characteristic peaks of polysaccharides and have been identified in the spectra of xylene and glycan polysaccharides. The peak found at 3355 cm −1 is related to the tensile vibration of the O–H bond [ 96 , 97 ].…”