Oxytocin does not contribute to the effects of cervical dilation on progesterone secretion and embryonic development in mares

Effects of repeated embryo flushing without PGF 2α administration on luteal function, percentage of unwanted pregnancy and subsequent fertility in mares

“…However, they did report that two of the eight cervical dilation mares showed signs of bacterial endometritis with a sudden drop in progesterone concentration to basal levels and signs of endometritis (endometrial oedema and accumulation of IUF) following cervical T A B L E 3 Characteristics of embryo flushing (EF) cycles according to the Day of EF. manipulation, 13 similar to the five cycles with early luteolysis reported in the present study. A shortened luteal phase is a common sign of bacterial endometritis, 20 as endometrial inflammation caused by bacterial contamination during breeding or breaching of the cervix during dioestrus 21 can cause bacterial multiplication and sufficient prostaglandin release to lyse the CL.…”

Effects of repeated embryo flushing without PGF 2α administration on luteal function, percentage of unwanted pregnancy and subsequent fertility in mares

“…However, they did report that two of the eight cervical dilation mares showed signs of bacterial endometritis with a sudden drop in progesterone concentration to basal levels and signs of endometritis (endometrial oedema and accumulation of IUF) following cervical T A B L E 3 Characteristics of embryo flushing (EF) cycles according to the Day of EF. manipulation, 13 similar to the five cycles with early luteolysis reported in the present study. A shortened luteal phase is a common sign of bacterial endometritis, 20 as endometrial inflammation caused by bacterial contamination during breeding or breaching of the cervix during dioestrus 21 can cause bacterial multiplication and sufficient prostaglandin release to lyse the CL.…”

Relationship between colour flow Doppler sonographic assessment of corpus luteum activity and progesterone concentrations in mares after embryo transfer

“…The general preference is to use recipient mares that have ovulations after the donor, meaning that first pregnancy assessments invariably occurred before the onset of cyclical luteolysis which typically begins between days 13 and 15 after ovulation with a reported range of 10-17 days (Perkins et al, 1993;Ginther et al, 2007;Bollwein et al, 2002). Possibly and more importantly, the absence of any difference in CL function between pregnant and non-pregnant mares following ET indicates that the failure to establish pregnancy was not a factor of the induction of luteolysis as a result of cervical dilation during transfer or consequent contamination as has been proposed previously (Handler et al, 2003) which is consistent with findings in a previous survey of a commercial ET programme (DeLuca et al, 2011;Handler et al, 2006).…”

Pharmacokinetics and bioavailability of carbetocin after intravenous and intramuscular administration in cows and gilts

“…This is supported by our results, where the T 1/2λZ following IM administration was about twofold higher than for the IV route in cows. Furthermore, the T max (0.26 hr) in the study was similar to that in mares (20 min) after IM injection (Handler, ).…”

“…Furthermore, the T max (0.26 hr) in the study was similar to that in mares (20 min) after IM injection (Handler, 2006).…”

Effects of repeated embryo flushing without PGF 2α administration on luteal function, percentage of unwanted pregnancy and subsequent fertility in mares

“…However, they did report that two of the eight cervical dilation mares showed signs of bacterial endometritis with a sudden drop in progesterone concentration to basal levels and signs of endometritis (endometrial oedema and accumulation of IUF) following cervical T A B L E 3 Characteristics of embryo flushing (EF) cycles according to the Day of EF. manipulation, 13 similar to the five cycles with early luteolysis reported in the present study. A shortened luteal phase is a common sign of bacterial endometritis, 20 as endometrial inflammation caused by bacterial contamination during breeding or breaching of the cervix during dioestrus 21 can cause bacterial multiplication and sufficient prostaglandin release to lyse the CL.…”

Relationship between colour flow Doppler sonographic assessment of corpus luteum activity and progesterone concentrations in mares after embryo transfer

“…The general preference is to use recipient mares that have ovulations after the donor, meaning that first pregnancy assessments invariably occurred before the onset of cyclical luteolysis which typically begins between days 13 and 15 after ovulation with a reported range of 10-17 days (Perkins et al, 1993;Ginther et al, 2007;Bollwein et al, 2002). Possibly and more importantly, the absence of any difference in CL function between pregnant and non-pregnant mares following ET indicates that the failure to establish pregnancy was not a factor of the induction of luteolysis as a result of cervical dilation during transfer or consequent contamination as has been proposed previously (Handler et al, 2003) which is consistent with findings in a previous survey of a commercial ET programme (DeLuca et al, 2011;Handler et al, 2006).…”

Pharmacokinetics and bioavailability of carbetocin after intravenous and intramuscular administration in cows and gilts

“…This is supported by our results, where the T 1/2λZ following IM administration was about twofold higher than for the IV route in cows. Furthermore, the T max (0.26 hr) in the study was similar to that in mares (20 min) after IM injection (Handler, ).…”

“…Furthermore, the T max (0.26 hr) in the study was similar to that in mares (20 min) after IM injection (Handler, 2006).…”

Effects of repeated embryo flushing without PGF 2α administration on luteal function, percentage of unwanted pregnancy and subsequent fertility in mares

“…However, they did report that two of the eight cervical dilation mares showed signs of bacterial endometritis with a sudden drop in progesterone concentration to basal levels and signs of endometritis (endometrial oedema and accumulation of IUF) following cervical T A B L E 3 Characteristics of embryo flushing (EF) cycles according to the Day of EF. manipulation, 13 similar to the five cycles with early luteolysis reported in the present study. A shortened luteal phase is a common sign of bacterial endometritis, 20 as endometrial inflammation caused by bacterial contamination during breeding or breaching of the cervix during dioestrus 21 can cause bacterial multiplication and sufficient prostaglandin release to lyse the CL.…”

Relationship between colour flow Doppler sonographic assessment of corpus luteum activity and progesterone concentrations in mares after embryo transfer

“…The general preference is to use recipient mares that have ovulations after the donor, meaning that first pregnancy assessments invariably occurred before the onset of cyclical luteolysis which typically begins between days 13 and 15 after ovulation with a reported range of 10-17 days (Perkins et al, 1993;Ginther et al, 2007;Bollwein et al, 2002). Possibly and more importantly, the absence of any difference in CL function between pregnant and non-pregnant mares following ET indicates that the failure to establish pregnancy was not a factor of the induction of luteolysis as a result of cervical dilation during transfer or consequent contamination as has been proposed previously (Handler et al, 2003) which is consistent with findings in a previous survey of a commercial ET programme (DeLuca et al, 2011;Handler et al, 2006).…”

Pharmacokinetics and bioavailability of carbetocin after intravenous and intramuscular administration in cows and gilts

“…This is supported by our results, where the T 1/2λZ following IM administration was about twofold higher than for the IV route in cows. Furthermore, the T max (0.26 hr) in the study was similar to that in mares (20 min) after IM injection (Handler, ).…”

“…Furthermore, the T max (0.26 hr) in the study was similar to that in mares (20 min) after IM injection (Handler, 2006).…”