One in four people may develop symptomatic hip osteoarthritis in his or her lifetime

Murphy, Louise B.; Helmick, Charles G.; Schwartz, Todd A.; Renner, Jordan B.; Tudor, Gail; Koch, Gary G.; Dragomir, Anca; Kalsbeek, William D.; Luta, George; Jordan, Joanne M.

doi:10.1016/j.joca.2010.08.005

Cited by 300 publications

(236 citation statements)

References 37 publications

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“…1 The lifetime prevalence of symptomatic hip osteoarthritis is estimated at 25.3%, 2 while that of knee osteoarthritis is even higher at 44.7%. 3 The economic burden of osteoarthritis is substantial and consists of both direct costs (such as drugs,…”

Section: Introductionmentioning

confidence: 99%

Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis

et al. 2014

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Objective To determine whether there is sufficient evidence to conclude that exercise interventions are more effective than no exercise control and to compare the effectiveness of different exercise interventions in relieving pain and improving function in patients with lower limb osteoarthritis. Data sources Nine electronic databases searched from inception to March 2012.Study selection Randomised controlled trials comparing exercise interventions with each other or with no exercise control for adults with knee or hip osteoarthritis.Data extraction Two reviewers evaluated eligibility and methodological quality. Main outcomes extracted were pain intensity and limitation of function. Trial sequential analysis was used to investigate reliability and conclusiveness of available evidence for exercise interventions. Bayesian network meta-analysis was used to combine both direct (within trial) and indirect (between trial) evidence on treatment effectiveness.Results 60 trials (44 knee, two hip, 14 mixed) covering 12 exercise interventions and with 8218 patients met inclusion criteria. Sequential analysis showed that as of 2002 sufficient evidence had been accrued to show significant benefit of exercise interventions over no exercise control. For pain relief, strengthening, flexibility plus strengthening, flexibility plus strengthening plus aerobic, aquatic strengthening, and aquatic strengthening plus flexibility, exercises were significantly more effective than no exercise control. A combined intervention of strengthening, flexibility, and aerobic exercise was also significantly more effective than no exercise control for improving limitation in function (standardised mean difference −0.63, 95% credible interval −1.16 to −0.10). ConclusionsAs of 2002 sufficient evidence had accumulated to show significant benefit of exercise over no exercise in patients with osteoarthritis, and further trials are unlikely to overturn this result. An approach combining exercises to increase strength, flexibility, and aerobic capacity is likely to be most effective in the management of lower limb osteoarthritis. The evidence is largely from trials in patients with knee osteoarthritis. PROSPERO (www.crd.york.ac.uk/prospero/) No CRD42012002267. Protocol registration IntroductionOsteoarthritis is the most common form of arthritis and one of the leading causes of pain and disability worldwide.1 The lifetime prevalence of symptomatic hip osteoarthritis is estimated at 25.3%, 2 while that of knee osteoarthritis is even higher at 44.7%. 3 The economic burden of osteoarthritis is substantial and consists of both direct costs (such as drugs, Between 1999 and 2000 in the United Kingdom, about 36 million working days were lost because of osteoarthritis alone, leading to an estimated £3.2bn (€3.8bn, $5.1bn) in productivity losses, with the total cost to the UK economy being estimated at 1% of gross national product per year. 1 In the United States, the estimated incremental cost of medical care expenditures and earnings losses for people ...

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Section: Introductionmentioning

confidence: 99%

Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis

et al. 2014

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“…Over 40 million Europeans are presently affected by OA [30]. Two studies have identified a 45% and 25% lifetime risk of developing knee and hip OA, respectively [31,32]. Furthermore, treatment is costly, currently estimated as representing 1:2.5% of gross national product [33].…”

Section: Asc Potential In Osteoarticular Disease: Osteoarthritis (Oa)mentioning

confidence: 99%

Adipose derived stem cells for regenerative therapy in osteoarticular diseases

Pers

Jørgensen

2016

Hormone Molecular Biology and Clinical Investigation

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Abstract:In the recent years, adipose derived stem cells (ASCs) led to significant findings in the field of regenerative therapy. ASCs have various biological properties and capacity as differentiation in three lineages (chondrocytes, osteocytes and adipocytes) or immunomodulation by releasing paracrine factors. Osteoarthritis (OA) is the most frequent osteoarticular disease characterized by none curative treatment. We reviewed all current data on the proof of concept of ASCs in OA pathophysiology as well as an inventory of ASC promising cell therapy in OA.

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“…The disease known as hip osteoarthritis is a common highly painful disabling joint disease with no known cure affecting a large proportion of the adult population [1,2]. One potentially preventable factor that may mediate or moderate the onset and progression of hip osteoarthritis is obesity [3].…”

Section: Introductionmentioning

confidence: 99%

Hip osteoarthritis surgical profiles and morbid obesity: a case series and literature review

Marks¹

2016

Clin Case Rep Rev

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One in four people may develop symptomatic hip osteoarthritis in his or her lifetime

Cited by 300 publications

References 37 publications

Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis

Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis

Adipose derived stem cells for regenerative therapy in osteoarticular diseases

Hip osteoarthritis surgical profiles and morbid obesity: a case series and literature review

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