Neurocognitive performance and negative symptoms: Are they equal in explaining disability in schizophrenia outpatients?

Effects of Long-Term Institutionalization on the Linguistic-Communicative Performance of Patients with Schizophrenia

“…The relationship between educational attainment and cognitive reserve is noteworthy, suggesting that higher educational levels may facilitate greater linguistic fluency despite the obstacles presented by prolonged institutionalization. This finding is consistent with cognitive theories proposing that education enhances the ability to utilize cognitive resources adaptively, thereby supporting language processing and communicative engagement [ 8 , 9 ]. Therefore, incorporating educational programs into therapeutic frameworks could promote cognitive development that offsets the losses experienced due to long-term institutionalization [ 18 ].…”

Effects of Long-Term Institutionalization on the Linguistic-Communicative Performance of Patients with Schizophrenia

“…The relationship between educational attainment and cognitive reserve is noteworthy, suggesting that higher educational levels may facilitate greater linguistic fluency despite the obstacles presented by prolonged institutionalization. This finding is consistent with cognitive theories proposing that education enhances the ability to utilize cognitive resources adaptively, thereby supporting language processing and communicative engagement [ 8 , 9 ]. Therefore, incorporating educational programs into therapeutic frameworks could promote cognitive development that offsets the losses experienced due to long-term institutionalization [ 18 ].…”

Correlating cognitive functions to symptom domains and insight in Egyptian patients with schizophrenia

“…Contrary to our results, the study carried by Bozikas et al (2004) and Lindsberg et al (2009) reported that the severe degree of negative symptoms was associated with lowered performance of the digit span task and audible attention problem (Bozikas et al, 2004;Lindsberg et al, 2009). Another study by Villalta-Gil et al (2006) reported that patients with schizophrenia who had severe negative symptoms expressed poor performance in tasks concerning verbal memory, attention, and working memory (Villalta-Gil et al, 2006). Our findings pointed to the significant correlation between PANSS subscales and specific cognitive deficits.…”

Real‐Life Functioning in 22q11.2 Deletion Syndrome in Relation to Neurocognitive Abilities and Psychotic Symptoms: A Comparison With Idiopathic Schizophrenia

“…Our findings suggest that negative symptoms would impact patients' social functioning regardless of what is the genetic aetiology of their psychotic illness; this aspect may corroborate what has been previously reported about 22q11.2DS (Schneider et al 2019), in line with evidence about both premorbid conditions and full-blown psychoses (Herbener and Harrow 2004), particularly concerning apathy (Liemburg et al 2013;Messinger et al 2011;Ventura et al 2013). Neurocognitive impairments and negative symptoms would predict real-life functioning in schizophrenic patients, both through mediational or direct models (Davies and Greenwood 2020;Milev et al 2005;Villalta-Gil et al 2006); a common aetiopathogenetic origin within negative symptoms, social cognitive deficits and interpersonal skills difficulties (Fett et al 2011) might be hypothesized. Psychotic symptoms arising from an ascertained genetic basis on one side and a multifactorial condition on the other would share a common phenomenology similarly impacting patients' social functioning, thus shedding light on the neurobiological basis of schizophrenia through a better knowledge of its endophenotypes.…”

Effects of Long-Term Institutionalization on the Linguistic-Communicative Performance of Patients with Schizophrenia

“…The relationship between educational attainment and cognitive reserve is noteworthy, suggesting that higher educational levels may facilitate greater linguistic fluency despite the obstacles presented by prolonged institutionalization. This finding is consistent with cognitive theories proposing that education enhances the ability to utilize cognitive resources adaptively, thereby supporting language processing and communicative engagement [ 8 , 9 ]. Therefore, incorporating educational programs into therapeutic frameworks could promote cognitive development that offsets the losses experienced due to long-term institutionalization [ 18 ].…”

Correlating cognitive functions to symptom domains and insight in Egyptian patients with schizophrenia

“…Contrary to our results, the study carried by Bozikas et al (2004) and Lindsberg et al (2009) reported that the severe degree of negative symptoms was associated with lowered performance of the digit span task and audible attention problem (Bozikas et al, 2004;Lindsberg et al, 2009). Another study by Villalta-Gil et al (2006) reported that patients with schizophrenia who had severe negative symptoms expressed poor performance in tasks concerning verbal memory, attention, and working memory (Villalta-Gil et al, 2006). Our findings pointed to the significant correlation between PANSS subscales and specific cognitive deficits.…”

Real‐Life Functioning in 22q11.2 Deletion Syndrome in Relation to Neurocognitive Abilities and Psychotic Symptoms: A Comparison With Idiopathic Schizophrenia

“…Our findings suggest that negative symptoms would impact patients' social functioning regardless of what is the genetic aetiology of their psychotic illness; this aspect may corroborate what has been previously reported about 22q11.2DS (Schneider et al 2019), in line with evidence about both premorbid conditions and full-blown psychoses (Herbener and Harrow 2004), particularly concerning apathy (Liemburg et al 2013;Messinger et al 2011;Ventura et al 2013). Neurocognitive impairments and negative symptoms would predict real-life functioning in schizophrenic patients, both through mediational or direct models (Davies and Greenwood 2020;Milev et al 2005;Villalta-Gil et al 2006); a common aetiopathogenetic origin within negative symptoms, social cognitive deficits and interpersonal skills difficulties (Fett et al 2011) might be hypothesized. Psychotic symptoms arising from an ascertained genetic basis on one side and a multifactorial condition on the other would share a common phenomenology similarly impacting patients' social functioning, thus shedding light on the neurobiological basis of schizophrenia through a better knowledge of its endophenotypes.…”

Effects of Long-Term Institutionalization on the Linguistic-Communicative Performance of Patients with Schizophrenia

“…The relationship between educational attainment and cognitive reserve is noteworthy, suggesting that higher educational levels may facilitate greater linguistic fluency despite the obstacles presented by prolonged institutionalization. This finding is consistent with cognitive theories proposing that education enhances the ability to utilize cognitive resources adaptively, thereby supporting language processing and communicative engagement [ 8 , 9 ]. Therefore, incorporating educational programs into therapeutic frameworks could promote cognitive development that offsets the losses experienced due to long-term institutionalization [ 18 ].…”

Correlating cognitive functions to symptom domains and insight in Egyptian patients with schizophrenia

“…Contrary to our results, the study carried by Bozikas et al (2004) and Lindsberg et al (2009) reported that the severe degree of negative symptoms was associated with lowered performance of the digit span task and audible attention problem (Bozikas et al, 2004;Lindsberg et al, 2009). Another study by Villalta-Gil et al (2006) reported that patients with schizophrenia who had severe negative symptoms expressed poor performance in tasks concerning verbal memory, attention, and working memory (Villalta-Gil et al, 2006). Our findings pointed to the significant correlation between PANSS subscales and specific cognitive deficits.…”

Real‐Life Functioning in 22q11.2 Deletion Syndrome in Relation to Neurocognitive Abilities and Psychotic Symptoms: A Comparison With Idiopathic Schizophrenia

“…Our findings suggest that negative symptoms would impact patients' social functioning regardless of what is the genetic aetiology of their psychotic illness; this aspect may corroborate what has been previously reported about 22q11.2DS (Schneider et al 2019), in line with evidence about both premorbid conditions and full-blown psychoses (Herbener and Harrow 2004), particularly concerning apathy (Liemburg et al 2013;Messinger et al 2011;Ventura et al 2013). Neurocognitive impairments and negative symptoms would predict real-life functioning in schizophrenic patients, both through mediational or direct models (Davies and Greenwood 2020;Milev et al 2005;Villalta-Gil et al 2006); a common aetiopathogenetic origin within negative symptoms, social cognitive deficits and interpersonal skills difficulties (Fett et al 2011) might be hypothesized. Psychotic symptoms arising from an ascertained genetic basis on one side and a multifactorial condition on the other would share a common phenomenology similarly impacting patients' social functioning, thus shedding light on the neurobiological basis of schizophrenia through a better knowledge of its endophenotypes.…”