“…Along with microtubules and intermediate filaments, actin is a major component of the cytoskeleton that defines global and local cellular architecture. Decades of research on the actin cytoskeleton has revealed a plethora of essential roles of actin in cell migration, cell adhesion, mitochondrial dynamics, muscle contraction, protein trafficking, cell division, membrane organization, mechanotransduction and tension sensing, nuclear matrix association, chromatin remodeling and regulation of transcription (Ampe and Van Troys, 2017;Bruser and Bogdan, 2017;Galkin et al, 2012;Lehtimaki et al, 2017;Luxenburg and Geiger, 2017;Pollard, 2017;Sanger et al, 2017;Sheterline et al, 1998;Viita and Vartiainen, 2017).…”