La rime et la déraison : l'épître en vers dans le temps de la Fronde

Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy

“…*P<.05, compared to the control (B6+Dp); +P<.05, compared to Flg ft +Dp (n=6, each group) may activate PAR-2 and Toll-like receptors on keratinocytes. 26,27 Meanwhile, the dendrites of activated LCs penetrate the weakened tight junctions of the upper stratum granulosum and take up the penetrating allergens. 28 Such percutaneous sensitization and chronic repeated allergen challenges via different routes, such as the lungs, nasal cavities and intestinal tract, are speculated to manifest as the atopic march.…”

Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy

“…*P<.05, compared to the control (B6+Dp); +P<.05, compared to Flg ft +Dp (n=6, each group) may activate PAR-2 and Toll-like receptors on keratinocytes. 26,27 Meanwhile, the dendrites of activated LCs penetrate the weakened tight junctions of the upper stratum granulosum and take up the penetrating allergens. 28 Such percutaneous sensitization and chronic repeated allergen challenges via different routes, such as the lungs, nasal cavities and intestinal tract, are speculated to manifest as the atopic march.…”

Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans

“…This is in part because of the enterotoxins produced by the Staphyloccocus species that both exacerbate and prolong the eczema. Briot et al reported (28) that LEKTI-deficient keratinocytes, KLK5 hyperactivity activates proinflammatory signalling, leading to the recruitment of eosinophilic and mast cells, which is reminiscent of AD-like skin lesion in Netherton's syndrome, independent from skin barrier defect, environmental stimuli, and adaptive immune system. Through genotyping the SPINK5 gene, we found that six SNPs (rs17718511, rs17860502, KN0001820, rs60978485, rs17718737, and rs1422985) and the haplotype TAA (rs60978485, rs6892205, rs2303064) in the SPINK5 gene show significant differences between the AD group and the control group.…”

Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy

“…*P<.05, compared to the control (B6+Dp); +P<.05, compared to Flg ft +Dp (n=6, each group) may activate PAR-2 and Toll-like receptors on keratinocytes. 26,27 Meanwhile, the dendrites of activated LCs penetrate the weakened tight junctions of the upper stratum granulosum and take up the penetrating allergens. 28 Such percutaneous sensitization and chronic repeated allergen challenges via different routes, such as the lungs, nasal cavities and intestinal tract, are speculated to manifest as the atopic march.…”

Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans

“…This is in part because of the enterotoxins produced by the Staphyloccocus species that both exacerbate and prolong the eczema. Briot et al reported (28) that LEKTI-deficient keratinocytes, KLK5 hyperactivity activates proinflammatory signalling, leading to the recruitment of eosinophilic and mast cells, which is reminiscent of AD-like skin lesion in Netherton's syndrome, independent from skin barrier defect, environmental stimuli, and adaptive immune system. Through genotyping the SPINK5 gene, we found that six SNPs (rs17718511, rs17860502, KN0001820, rs60978485, rs17718737, and rs1422985) and the haplotype TAA (rs60978485, rs6892205, rs2303064) in the SPINK5 gene show significant differences between the AD group and the control group.…”

Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy

“…*P<.05, compared to the control (B6+Dp); +P<.05, compared to Flg ft +Dp (n=6, each group) may activate PAR-2 and Toll-like receptors on keratinocytes. 26,27 Meanwhile, the dendrites of activated LCs penetrate the weakened tight junctions of the upper stratum granulosum and take up the penetrating allergens. 28 Such percutaneous sensitization and chronic repeated allergen challenges via different routes, such as the lungs, nasal cavities and intestinal tract, are speculated to manifest as the atopic march.…”

Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans

“…This is in part because of the enterotoxins produced by the Staphyloccocus species that both exacerbate and prolong the eczema. Briot et al reported (28) that LEKTI-deficient keratinocytes, KLK5 hyperactivity activates proinflammatory signalling, leading to the recruitment of eosinophilic and mast cells, which is reminiscent of AD-like skin lesion in Netherton's syndrome, independent from skin barrier defect, environmental stimuli, and adaptive immune system. Through genotyping the SPINK5 gene, we found that six SNPs (rs17718511, rs17860502, KN0001820, rs60978485, rs17718737, and rs1422985) and the haplotype TAA (rs60978485, rs6892205, rs2303064) in the SPINK5 gene show significant differences between the AD group and the control group.…”