La rime et la déraison : l'épître en vers dans le temps de la Fronde

Briot, Frédéric

doi:10.3406/licla.1993.1721

Cited by 3 publications

(2 citation statements)

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“…*P<.05, compared to the control (B6+Dp); +P<.05, compared to Flg ft +Dp (n=6, each group) may activate PAR-2 and Toll-like receptors on keratinocytes. 26,27 Meanwhile, the dendrites of activated LCs penetrate the weakened tight junctions of the upper stratum granulosum and take up the penetrating allergens. 28 Such percutaneous sensitization and chronic repeated allergen challenges via different routes, such as the lungs, nasal cavities and intestinal tract, are speculated to manifest as the atopic march.…”

Section: Discussionmentioning

confidence: 99%

Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy

Lee

Kim

et al. 2016

Experimental Dermatology

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The presence of congenitally impaired skin barrier followed by atopic dermatitis (AD) is an initial step in the atopic march. The maintenance of acidic pH in the stratum corneum (SC) has been suggested as a therapeutic or preventive strategy for barrier impairment caused by skin inflammation. To determine whether an AD murine model, flaky tail mice, with inherited filaggrin deficiency could develop airway inflammation by repeated topical application followed by nasal inhalation of house dust mite (HDM) antigen (defined as a novel "atopic march animal model"), and whether maintenance of an acidic SC environment by continuous application of acidic cream could interrupt the following atopic march. During the course of HDM treatment, acidic cream (pH2.8) or neutral cream (pH7.4) was applied to flaky tail mice twice daily. Repeated applications and inhalations of HDM to flaky tail mice induced AD skin lesions followed by respiratory allergies. Maintenance of SC acidity inhibited the occurrence of respiratory allergic inflammation as well as AD-like skin lesions. Collectively, a novel atopic march model could be developed by repeated epicutaneous and nasal applications of HDM to flaky tail mice, and that the acidification of SC could prevent the atopic march from AD to respiratory allergy.

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Section: Discussionmentioning

confidence: 99%

Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy

Lee

Kim

et al. 2016

Experimental Dermatology

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“…This is in part because of the enterotoxins produced by the Staphyloccocus species that both exacerbate and prolong the eczema. Briot et al reported (28) that LEKTI-deficient keratinocytes, KLK5 hyperactivity activates proinflammatory signalling, leading to the recruitment of eosinophilic and mast cells, which is reminiscent of AD-like skin lesion in Netherton's syndrome, independent from skin barrier defect, environmental stimuli, and adaptive immune system. Through genotyping the SPINK5 gene, we found that six SNPs (rs17718511, rs17860502, KN0001820, rs60978485, rs17718737, and rs1422985) and the haplotype TAA (rs60978485, rs6892205, rs2303064) in the SPINK5 gene show significant differences between the AD group and the control group.…”

Section: Discussionmentioning

confidence: 99%

Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans

Namkung

Lee

Kim

et al. 2010

Experimental Dermatology

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Clinical studies, including twin studies, support the concept that the risk of atopic dermatitis (AD) may be mediated through skin-specific genes, rather than simply through systemic immune or atopy risk genes. The SPINK5 gene is expressed on epithelial surfaces and may provide protection against other allergenic serine proteases. Mutations in the SPINK5 gene result in Netherton syndrome, a disorder characterised by AD, ichthyosis, and elevated serum IgE levels. We genotyped 21 single nucleotide polymorphisms (SNPs) from the SPINK5 gene for 1090 case-control samples (631 patients with AD and 459 normal controls) and analysed the SNPs and haplotypes in this gene and also searched for gene-gene interactions between SPINK5 and the DEFB1 gene that we previously reported. Six SNPs [rs17718511 (P = 0.026), rs17860502 (P = 0.024), KN0001820 (P = 0.045), rs60978485 (P = 0.007), rs17718737 (P = 0.02), and rs1422985 (P = 0.038)] and the haplotype TAA (rs60978485, rs6892205, rs2303064; P = 0.023) in the SPINK5 gene showed significant different allelic or genotypic distributions between the AD group and the control group. We also found that four SNPs [rs17718511 (P = 0.033), rs17860502 (P = 0.031), rs60978485 (P = 0.005), rs17718737 (P = 0.023)] and the haplotype TAA (P = 0.02) in the SPINK5 gene showed associations with the susceptibility of the allergic type of AD (ADe). In addition to this finding, we speculate that the SNPs from DEFB1 and SPINK5 affect the individual susceptibility to development of ADe in an additive manner. This study provides evidence for a significant interaction between allergens and the SPINK5 gene that may contribute to ADe susceptibility.

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Exploiter un corpus de données textuelles sans post-traitement : l’écriture burlesque de la Fronde

Abiven¹,

Tanguy²,

Lejeune³

2021

revuehn

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humanités numériquesExploiter un corpus de données textuelles sans post-traitement : l'écriture burlesque de la Fronde Résumés veal the specificities of "burlesque writing" in this political context. Then, the problem of acquiring textual data arises: the process of digitizing old printed matter and its evaluation are thus exposed. We choose to exploit these raw data, without post-processing or text correction, which still seems to allow us to obtain results (regarding lexicon, metre or enunciation), with various methods (textometry and observation of character n-grams). We thus show the specificity, in the burlesque writing of the Fronde, of some literary motifs or rhymes. The aim is therefore to present the approach of a corpus in all the steps of the process: from the selection of data, their acquisition, and their transformation into a corpus, to their statistical and algorithmic exploitation, and their interpretation through text mining.

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La rime et la déraison : l'épître en vers dans le temps de la Fronde

Cited by 3 publications

References 0 publications

Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy

Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy

Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans

Exploiter un corpus de données textuelles sans post-traitement : l’écriture burlesque de la Fronde

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