Inverse effect of mucinous component on survival in stage III colorectal cancer

Abstract

Although ACM is similar to CAC with regard to estimated risk of recurrence, the outcome is extremely poor once recurrence occurs and is identical to MAC; one of the most aggressive phenotypes of stage III CRC. Thus, both MAC and ACM are adverse prognostic factors for OS.

Trends of incidence and survival in patients with gastrointestinal mucinous adenocarcinoma

“…Consistent with the current knowledge that the grade and stage of MA are directly correlated with the prognostic outcome ( 25 , 26 ), our study reveals that advanced stage MA and a poorly differentiated grade are independently associated with poorer outcomes and more metastatic risk, ( 27 , 28 ); these findings are in agreement with other reports. Interestingly, what is promising is that survival outcomes for MA have been improving over a period of 15 years, especially for patients with advanced stage disease and distant metastasis.…”

Trends of incidence and survival in patients with gastrointestinal mucinous adenocarcinoma

“…Consistent with the current knowledge that the grade and stage of MA are directly correlated with the prognostic outcome ( 25 , 26 ), our study reveals that advanced stage MA and a poorly differentiated grade are independently associated with poorer outcomes and more metastatic risk, ( 27 , 28 ); these findings are in agreement with other reports. Interestingly, what is promising is that survival outcomes for MA have been improving over a period of 15 years, especially for patients with advanced stage disease and distant metastasis.…”

Prognostic significance of mucinous component in hilar cholangiocarcinoma after curative‐intent resection

“…10,17,18 Conversely, other investigators have suggested that CAM is significantly associated with a worse prognosis than conventional adenocarcinoma. 19,20 In our study, we found that HCM patients had a between molecular features and prognosis. For instance, microsatellite instability (MSI) was confirmed more frequent in CAM and was closely associated with clinicopathological features.…”

“…Several studies have demonstrated that CAM has similar outcomes compared with conventional adenocarcinoma, with no impact on prognosis . Conversely, other investigators have suggested that CAM is significantly associated with a worse prognosis than conventional adenocarcinoma . In our study, we found that HCM patients had a remarkably worse long‐term survival compared with conventional HC patients.…”

First‐line therapy of bevacizumab plus chemotherapy versus cetuximab plus chemotherapy for metastatic colorectal cancer patients with mucinous adenocarcinoma or mucinous component

“…In terms of epidemiological features of mCRC patients with MA/MC, the incidence (141/620, 22.7%) in our study was greater than that previously reported in Asia (5%–10%) 37 . Considering that the clinicopathological characteristic of MC resembled that of MA in the mCRC population, 19,38 we incorporated patients with MC and MA into one group. Other characteristics of MA/MC in our study, such as higher rates of right‐side (34.8%), poor differentiation (42.6%), RAS‐mutant (43.5%), BRAF‐mutant (7.5%), MSI (5.0%), and the presence of peritoneal metastasis (33.3%), were similar to those reported in previous studies 39,40 …”

Trends of incidence and survival in patients with gastrointestinal mucinous adenocarcinoma

“…Consistent with the current knowledge that the grade and stage of MA are directly correlated with the prognostic outcome ( 25 , 26 ), our study reveals that advanced stage MA and a poorly differentiated grade are independently associated with poorer outcomes and more metastatic risk, ( 27 , 28 ); these findings are in agreement with other reports. Interestingly, what is promising is that survival outcomes for MA have been improving over a period of 15 years, especially for patients with advanced stage disease and distant metastasis.…”

Prognostic significance of mucinous component in hilar cholangiocarcinoma after curative‐intent resection

“…10,17,18 Conversely, other investigators have suggested that CAM is significantly associated with a worse prognosis than conventional adenocarcinoma. 19,20 In our study, we found that HCM patients had a between molecular features and prognosis. For instance, microsatellite instability (MSI) was confirmed more frequent in CAM and was closely associated with clinicopathological features.…”

“…Several studies have demonstrated that CAM has similar outcomes compared with conventional adenocarcinoma, with no impact on prognosis . Conversely, other investigators have suggested that CAM is significantly associated with a worse prognosis than conventional adenocarcinoma . In our study, we found that HCM patients had a remarkably worse long‐term survival compared with conventional HC patients.…”

First‐line therapy of bevacizumab plus chemotherapy versus cetuximab plus chemotherapy for metastatic colorectal cancer patients with mucinous adenocarcinoma or mucinous component

“…In terms of epidemiological features of mCRC patients with MA/MC, the incidence (141/620, 22.7%) in our study was greater than that previously reported in Asia (5%–10%) 37 . Considering that the clinicopathological characteristic of MC resembled that of MA in the mCRC population, 19,38 we incorporated patients with MC and MA into one group. Other characteristics of MA/MC in our study, such as higher rates of right‐side (34.8%), poor differentiation (42.6%), RAS‐mutant (43.5%), BRAF‐mutant (7.5%), MSI (5.0%), and the presence of peritoneal metastasis (33.3%), were similar to those reported in previous studies 39,40 …”

Trends of incidence and survival in patients with gastrointestinal mucinous adenocarcinoma

“…Consistent with the current knowledge that the grade and stage of MA are directly correlated with the prognostic outcome ( 25 , 26 ), our study reveals that advanced stage MA and a poorly differentiated grade are independently associated with poorer outcomes and more metastatic risk, ( 27 , 28 ); these findings are in agreement with other reports. Interestingly, what is promising is that survival outcomes for MA have been improving over a period of 15 years, especially for patients with advanced stage disease and distant metastasis.…”

Prognostic significance of mucinous component in hilar cholangiocarcinoma after curative‐intent resection

“…10,17,18 Conversely, other investigators have suggested that CAM is significantly associated with a worse prognosis than conventional adenocarcinoma. 19,20 In our study, we found that HCM patients had a between molecular features and prognosis. For instance, microsatellite instability (MSI) was confirmed more frequent in CAM and was closely associated with clinicopathological features.…”

“…Several studies have demonstrated that CAM has similar outcomes compared with conventional adenocarcinoma, with no impact on prognosis . Conversely, other investigators have suggested that CAM is significantly associated with a worse prognosis than conventional adenocarcinoma . In our study, we found that HCM patients had a remarkably worse long‐term survival compared with conventional HC patients.…”

First‐line therapy of bevacizumab plus chemotherapy versus cetuximab plus chemotherapy for metastatic colorectal cancer patients with mucinous adenocarcinoma or mucinous component

“…In terms of epidemiological features of mCRC patients with MA/MC, the incidence (141/620, 22.7%) in our study was greater than that previously reported in Asia (5%–10%) 37 . Considering that the clinicopathological characteristic of MC resembled that of MA in the mCRC population, 19,38 we incorporated patients with MC and MA into one group. Other characteristics of MA/MC in our study, such as higher rates of right‐side (34.8%), poor differentiation (42.6%), RAS‐mutant (43.5%), BRAF‐mutant (7.5%), MSI (5.0%), and the presence of peritoneal metastasis (33.3%), were similar to those reported in previous studies 39,40 …”