Interstitial Lung Disease Induced by Crizotinib in Non-Small-Cell Lung Cancer

Abstract

The treatment of advanced non-small-cell lung cancer shifted with the development of molecular-targeted therapies, like the tyrosine kinase inhibitors. One example of tyrosine kinase inhibitors is crizotinib, an anaplastic lymphoma tyrosine kinase inhibitor, which targets an echinoderm microtubule-associated protein-like-4-anaplastic lymphoma kinase gene fusion. This mutation is found in only 2% to 7% of non-small-cell lung cancer cases. Although these new therapies have shown promising results, the occurrence of interstitial lung disease as a side effect could be problematic. As the diagnosis of drug-related-interstitial lung disease is difficult to make, computed tomography is an important diagnostic tool. The recognition of computed tomography manifestations of tyrosine kinase inhibitors -induced interstitial lung disease is the key for an early recognition and management of this pulmonary toxicity. We aim to raise awareness of tyrosine kinase inhibitors-induced interstitial lung disease, by reporting the first case of a Portuguese patient treated with crizotinib for non-small-cell lung cancer who developed drug-induced interstitial lung disease.

Preventive and Therapeutic Effects of Punica granatum (Pomegranate) in Respiratory and Digestive Diseases: A Review

“…Chronic respiratory diseases are one of the leading causes of death globally. Victims of lung disorders frequently experience long-term difficulties, with one of the major causes being treatment side effects as well as psychosocial struggles [17]. Respiratory diseases are characterized by unrestricted cell proliferation and no single defined cause, but they are associated with several risk factors, including tobacco use, infection, radiation exposure, air pollution, obesity, and alcohol consumption.…”

Therapeutic properties of Punica granatum L (pomegranate) and its applications in lung‐based diseases: A detailed review

“…Chronic respiratory diseases (CRD) are among the leading causes of mortality worldwide. Victims of lung disorders often experience long-lasting difficulties, where one of the major causes includes treatment side effects along with psychosocial struggles (Tereso et al, 2019). CRD is of unrestricted cell proliferation.…”

Post Chemo Lung Toxicity: A Less Visited Domain

“…Most treatment once it is in advanced stages .However commonly associated radiological findings on owing to cytotoxic effects, they are known to have chest CT are ground glass haze (with or without 1, 2 septal thickening) ,patches of consolidations and delirious effects on unwanted targets . 3,4 bronchiectatic changes. Furthermore symptoms Many international studies have been conducted related to chemotherapy induced lung diseases concentrating upon pulmonary toxicity due to are non-specific as well and do not correlate with chemotherapeutic drugs and their relation with radiological picture making the picture even more development of interstitial lung diseases claiming confusin g. Frequent ly associat ed symptoms [3][4][5][6][7] include shortness of breath, cough, chest pain there incidence to be as high as 10% .…”

“…3,4 bronchiectatic changes. Furthermore symptoms Many international studies have been conducted related to chemotherapy induced lung diseases concentrating upon pulmonary toxicity due to are non-specific as well and do not correlate with chemotherapeutic drugs and their relation with radiological picture making the picture even more development of interstitial lung diseases claiming confusin g. Frequent ly associat ed symptoms [3][4][5][6][7] include shortness of breath, cough, chest pain there incidence to be as high as 10% . Time however the patient might be as well be interval between start of chemotherapy and 1 appearance of lung changes can vary greatly asymptomatic.…”