Increase of the cytotoxic effect of Bothrops jararacussu venom on mouse extensor digitorum longus and soleus by potassium channel blockers and by Na+/K+-ATPase inhibition

A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization

“…As we previously described, the increase of plasma CK in mice reach a peak at 2 h after intramuscular injection and reflects the sarcolemma damage of skeletal muscle fibers, that we ascribe as myotoxicity [28]. We also showed that isolated mouse EDL or soleus muscle exposed to honeybee venom presents a quick and intense injury, revealed by the rate of CK release [38].…”

A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization

“…As we previously described, the increase of plasma CK in mice reach a peak at 2 h after intramuscular injection and reflects the sarcolemma damage of skeletal muscle fibers, that we ascribe as myotoxicity [28]. We also showed that isolated mouse EDL or soleus muscle exposed to honeybee venom presents a quick and intense injury, revealed by the rate of CK release [38].…”

Strophanthus sarmentosus Extracts and the Strophanthus Cardenolide Ouabain Inhibit Snake Venom Proteases from Echis ocellatus

“…Regarding snakes, ouabain increased the rate of creatine kinase release by Bothrops jararacussu crude venom in isolated mouse muscles [ 75 ]. Moderate rat brain NKA inactivation by PLA2 from Naja naja oxiana venom was accompanied by a decrease in the affinity for ouabain [ 76 ].…”

A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization

“…As we previously described, the increase of plasma CK in mice reach a peak at 2 h after intramuscular injection and reflects the sarcolemma damage of skeletal muscle fibers, that we ascribe as myotoxicity [28]. We also showed that isolated mouse EDL or soleus muscle exposed to honeybee venom presents a quick and intense injury, revealed by the rate of CK release [38].…”

Strophanthus sarmentosus Extracts and the Strophanthus Cardenolide Ouabain Inhibit Snake Venom Proteases from Echis ocellatus

“…Regarding snakes, ouabain increased the rate of creatine kinase release by Bothrops jararacussu crude venom in isolated mouse muscles [ 75 ]. Moderate rat brain NKA inactivation by PLA2 from Naja naja oxiana venom was accompanied by a decrease in the affinity for ouabain [ 76 ].…”

A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization

“…As we previously described, the increase of plasma CK in mice reach a peak at 2 h after intramuscular injection and reflects the sarcolemma damage of skeletal muscle fibers, that we ascribe as myotoxicity [28]. We also showed that isolated mouse EDL or soleus muscle exposed to honeybee venom presents a quick and intense injury, revealed by the rate of CK release [38].…”

Strophanthus sarmentosus Extracts and the Strophanthus Cardenolide Ouabain Inhibit Snake Venom Proteases from Echis ocellatus

“…Regarding snakes, ouabain increased the rate of creatine kinase release by Bothrops jararacussu crude venom in isolated mouse muscles [ 75 ]. Moderate rat brain NKA inactivation by PLA2 from Naja naja oxiana venom was accompanied by a decrease in the affinity for ouabain [ 76 ].…”