In Vitro and In Vivo Wound Healing and Anti‐Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae)

Abstract

Babassu (Attalea speciosa Mart. ex Spreng., Arecaceae) is a palm tree endemic to Brazil and found mainly in the borders of Amazon forest, where the harvesting of its fruits is an important source of income for more than 300,000 people. Among the communities of coconut breakers women, babassu oil is used in culinary, as fuel, and mostly as medicinal oil for the treatment of skin wounds and inflammation. This study aimed to evaluate in vitro and in vivo the wound healing effects of babassu oil. In vitro, babassu oil increased the migration of L929 fibroblasts, inhibited the production of nitric oxide by LPS-stimulated peritoneal macrophages, and increased the levels of INF-γ and IL-6 cytokines production. In vivo, babassu oil accelerated the healing process in a full-thickness splinted wound model, by an increase in the fibroblasts number, blood vessels, and collagen deposition in the wounds. The babassu oil also increased the recruitment of inflammatory cells into the wound site and showed an anti-inflammatory effect in a chronic ear edema model, reducing ear thickness, epidermal hyperplasia, and myeloperoxidase activity. Thus, these data corroborate the use of babassu oil in folk medicine as a remedy to treat skin wounds.

Integrated network pharmacology and experimental validation to explore the mechanisms underlying naringenin treatment of chronic wounds

“…The molecular docking experiment indicated that naringenin could bind tightly to these screened key target proteins. The endotoxin lipopolysaccharide (LPS) is a component of gram-negative bacteria and is widely used to simulate the inflammatory and oxidative stress state of wound healing in vitro 89 , 109 , 110 . LPS binds to Toll-like receptor 4 (TLR4) and activates multiple signalling pathways through signal transduction, including NF-κB p65/RELA and MAPKs, ultimately resulting in increased transcription of the proinflammatory cytokines TNF-α and IL-6 111 .…”

A Review of Potential Use of Amazonian Oils in the Synthesis of Organogels for Cosmetic Application

“…Babassu oil is rich in lauric acid, myristic acid, and oleic acid (Table 2) [89]. Lauric fats are very important in industry, as they are resistant to non-enzymatic oxidation and, unlike other saturated fats, they have a low and well-defined melting temperature [104].…”

Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis

“…The splinted full thickness model was used study the effects of recombinant myxoma virus-derived immune modulator M-T7 [49], of Babassu oil [50], of three-dimensional printed scaffolds and electrospun mats [51], of adult gingival multipotent mensenchymal stem cells [52], of induced pluripotent stem cells clay [53], of poly(lactic-co-glycolic acid) and vascular endothelial growth factor [54], and of renal dysfunction [44] on cutaneous wound healing.…”